AI Article Synopsis
- This study focused on diabetic nephropathy (DN) using the type 2 diabetic ZSF1 fa/fa rat model over a 41-week period.
- Researchers analyzed various aspects including biomarkers, kidney tissue structure, and gene expression to understand the disease better.
- The findings suggest that the ZSF1 rat model is valuable for studying the mechanisms of DN and testing potential treatments.
Article Abstract
This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/fa rat model. During this study, we conducted longitudinal analysis of biomarkers, renal histopathology, ultrastructural assessment, renal quantitative image analysis, and transcriptome analysis of glomerular-enriched tissue. We concluded that there is translational value for using the ZSF1 rat model in mechanistic and therapeutic intervention efficacy studies for type 2 DN.
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| http://dx.doi.org/10.1177/0192623318803278 | DOI Listing |
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