AI Article Synopsis
- Their structures were determined using several scientific techniques, including spectroscopy and mass spectrometry.
- The anti-inflammatory effects were tested, revealing that compounds A and 6 moderately inhibited nitric oxide production without being toxic, while compounds A and 5-8 effectively inhibited a key enzyme (α-glucosidase) with some showing strong potency.
Article Abstract
Four new coumestans dolichosins A - D (1: -4: ) were isolated from the roots of , together with four known compounds: isosojagol (5: ), phaseol (6: ), psoralidin (7: ), and 4″,5″-dehydroisopsoralidin (8: ). Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analyses, and the comparison with literature data of related compounds. The anti-inflammatory activity of these compounds (1: -8: ) was evaluated through the inhibition of nitric oxide production in lipopolysaccharide-activated murine macrophage RAW 264.7 cells, in which compounds 1: and 6: displayed moderate inhibitory activity and no cytotoxic effects. In a -glucosidase inhibitory assay, compounds 1: and 5: -8: exhibited appreciable inhibition on -glucosidase. Especially compounds 1, 7: , and 8: showed IC values lower than 20.0 µM.
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| http://dx.doi.org/10.1055/a-0746-8622 | DOI Listing |
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