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Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma (EMERALD-1): a multiregional, randomised, double-blind, placebo-controlled, phase 3 study.
Lancet
January 2025
Department of Diagnostic and Interventional Radiology, University of Pisa School of Medicine, Pisa, Italy.
Background: Transarterial chemoembolisation (TACE) is standard of care for patients with unresectable hepatocellular carcinoma that is amenable to embolisation; however, median progression-free survival is still approximately 7 months. We aimed to assess whether adding durvalumab, with or without bevacizumab, might improve progression-free survival.
Methods: In this multiregional, randomised, double-blind, placebo-controlled, phase 3 study (EMERALD-1), adults aged 18 years or older with unresectable hepatocellular carcinoma amenable to embolisation, an Eastern Cooperative Oncology Group performance status of 0 or 1 at enrolment, and at least one measurable intrahepatic lesion per modified Response Evaluation Criteria in Solid Tumours (RECIST) were enrolled at 157 medical sites including research centres and general and specialist hospitals in 18 countries.
Immunogenicity in mice and non-human primates of an Advax-CpG55.2-adjuvanted recombinant hemagglutinin seasonal quadrivalent influenza vaccine.
Vaccine
January 2025
Vaxine Pty Ltd, Warradale, Adelaide, SA 5046, Australia; Australian Respiratory and Sleep Medicine Institute Ltd, Adelaide, SA 5042, Australia. Electronic address:
Article Synopsis
- There's an urgent need to boost the effectiveness of seasonal influenza vaccines, with recombinant hemagglutinin showing potential benefits over traditional methods.
- In a study, two adjuvants (Advax-CpG55.2 and alum-CpG55.2) were tested to see if they could improve the immune response of a quadrivalent influenza vaccine (QIV) in mice.
- Results showed that the adjuvanted vaccines led to much higher levels of protective antibodies and significantly reduced illness in mice infected with the H1N1 strain, suggesting that this approach could be a better alternative for seasonal flu vaccinations.
Environmental and human health risk assessment of potentially toxic elements in rehabilitating iron mine lands in the Brazilian Amazon.
J Environ Manage
January 2025
Instituto Tecnológico Vale, Rua Boaventura da Silva, 955, Belém, 66055-090, PA, Brazil. Electronic address:
Waste pile substrates from Fe mining may carry potentially toxic elements (PTE). Rehabilitation efforts must maintain soil vegetation cover effectively, avoiding the dispersion of particulate matter and reducing the risk to the environment and human health. Therefore, this study aims to evaluate the pseudo-total and extractable contents, perform chemical fractionation, and assess the bioaccessibility and risk of PTE in waste piles of Fe mining in the Eastern Amazon.
View Article and Find Full Text PDFMetal Biomonitoring Through Arboreal Species in Riparian Ecosystems: as a Bioindicator Species.
Plants (Basel)
January 2025
Laboratorio de Investigaciones Ambientales, Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Av. Universidad, 1001, Col. Chamilpa, Cuernavaca C.P. 62209, Morelos, Mexico.
Water pollution by metals is a global environmental problem. In riparian ecosystems, metal pollution generates adverse effects on organisms and reduces water quality. The Cuautla River is of great ecological relevance and an important water supplier.
View Article and Find Full Text PDFContinuous theta-burst stimulation demonstrates language-network-specific causal effects on syntactic processing.
Neuroimage
January 2025
Max Planck Partner Group, School of International Chinese Language Education, Beijing Normal University, Beijing, China; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Electronic address:
Hierarchical syntactic structure processing is proposed to be at the core of the human language faculty. Syntactic processing is supported by the left fronto-temporal language network, including a core area in the inferior frontal gyrus as well as its interaction with the posterior temporal lobe (i.e.
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