AI Article Synopsis
- Traditional chelating agents like DTPA have been the go-to for removing actinides from the human body, but they mainly work in the blood serum.
- A new class of macromolecular decorporation agents is being explored for better effectiveness across different organs affected by plutonium.
- Polyethyleneimine methylenecarboxylate (PEI-MC) is a promising candidate because it can specifically target the liver and bones, improving treatment for organ contamination.
Article Abstract
Up until now, molecular chelating agents, such as diethylenetriamine pentaacetic acid (DTPA), have been the standard method for actinide human decorporation. Mainly active in blood serum, their distribution within the body is thus limited. To treat a wider range of organs affected by plutonium contamination, a potential new class of macromolecular decorporation agents is being studied. Polyethyleneimine methylenecarboxylate (PEI-MC) is one such example. It is being considered here because of its capacity for targeting the liver and bones.
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| http://dx.doi.org/10.1039/c8cc05206a | DOI Listing |
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