Background: Many insurance carriers continue to deny coverage for reduction mammaplasty unless a minimum amount of resected breast tissue per breast is achieved during surgery. This study investigates the accuracy of preoperative prediction that a minimum weight of 500 g can be resected and evaluates potential risk factors for not meeting this insurance requirement.
Methods: A retrospective review was performed on 445 patients with bilateral symptomatic macromastia who sought consultation for breast reduction surgery from 2007 to 2012. Women were included for analysis if they had documented predicted resection weights and underwent small-to-moderate breast reduction (< 1,000 g per side; n = 323). Relevant demographic information, mean predicted resection weight, and the mean actual resection weight were collected for analysis.
Results: Surgeon prediction of resection weight being over 500 g had a positive predictive value of 73%. In 61 patients (19%), the predicted weights were ≥ 500 g, but the actual weights were < 500 g. Thirty percentage of these 61 patients did not meet either Schnur or minimum weight requirements. Women with a body mass index < 30 were at significantly increased odds (odds ratio, 3.76; 95% confidence interval, 1.89-7.48; = 0.002) of not meeting the minimum weight requirement at surgery compared with patients with a body mass index ≥ 30.
Conclusions: The common insurance criterion of removing ≥ 500 g per breast during breast reduction surgery are not met in a distinct cohort of women who are clinically appropriate candidates. This risk is particularly increased in nonobese women possibly due to proportionately smaller breast mass compared with obese women.
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http://dx.doi.org/10.1097/GOX.0000000000001830 | DOI Listing |
Indian J Clin Biochem
January 2025
Department of Biology, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
The cystathionine beta-synthase (CBS) gene plays a critical role in numerous physiological processes, including cellular proliferation, bioenergetics, and redox balance, and has been implicated in many cancers, including breast and gastric cancers. Previous studies have suggested that VNTR polymorphism in intron 13 of the CBS gene may influence enzyme activity, as an increase in the number of repeats in this VNTR leads to a reduction in the activity of the CBS enzyme. In this case-control study, for the first time, we genotyped 107 patients with gastric cancer (and 111 healthy controls) and 138 patients with breast cancer (and 124 healthy controls) for the CBS VNTR polymorphism using PCR.
View Article and Find Full Text PDFFront Genet
January 2025
Discipline of Chinese and Western Integrative Medicine, Jiangxi University of Chinese Medicine, Nanchang, China.
Background: Triple-negative breast cancer (TNBC) is a heterogeneous disease with a worse prognosis. Despite ongoing efforts, existing therapeutic approaches show limited success in improving early recurrence and survival outcomes for TNBC patients. Therefore, there is an urgent need to discover novel and targeted therapeutic strategies, particularly those focusing on the immune infiltrate in TNBC, to enhance diagnosis and prognosis for affected individuals.
View Article and Find Full Text PDFBiol Direct
January 2025
Department of Urology, The First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang, Liaoning, China.
Background: Bladder cancer (BC) is a malignant tumor. Methyltransferase-like 7B (MEETL7B) is a methyltransferase and its role in BC has not yet been revealed.
Method: Stable METTL7B knockdown or overexpression were achieved by lentiviral transduction in SW780 and TCCSUP cell lines.
Dentomaxillofac Radiol
January 2025
Assist. Prof. Dr, Selcuk University Faculty of Medicine, Department of Radiation Oncology, Konya, 42130, Turkiye.
Objectives: Due to the increasing use of cone-beam computed tomography (CBCT) in dentistry and considering the effects of radiation on radiosensitive organs, the aim of this study was to investigate the effect of shielding on absorbed dose of eyes, thyroid and breasts in scans conducted with different parameters using two different fields of view (FOV).
Methods: Dose measurements were calculated on a tissue-equivalent female phantom by repeating each scanning parameter three times and placing at least two thermoluminescent dosimeters (TLD) on each organ, with the averages then taken. The same CBCT scans were performed in two different FOV with shielding including thyroid collar, radiation safety glasses and lead apron and without shielding.
Plast Reconstr Surg Glob Open
January 2025
From the Division of Plastic and Reconstructive Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA.
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