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[A 14-year-old boy with painful oral lesions].
Ned Tijdschr Geneeskd
January 2025
Maasstad Ziekenhuis, afd. Kindergeneeskunde, Rotterdam.
This case concerns a boy presenting with oral pain and multiple mucocutaneous lesions such as mucositis, conjunctivitis, and a rash on the trunk, extremities, and genitalia. The presence of mild respiratory complaints raised suspicion of an extrapulmonary manifestation of , known as -induced Rash and Mucositis (MIRM). The patient underwent conservative treatment and was monitored to prevent chronic sequels such as ocular damage or sicca keratoconjunctivits.
View Article and Find Full Text PDFA 33-year-old female presented with coryzal symptoms, facial swelling, severe haemorrhagic stomatitis, blistering oral mucositis, conjunctival injection and a sparse targetoid rash on the back and face, requiring admission to hospital. She had received the seasonal influenza vaccination 3 days prior to feeling unwell. Differential diagnosis included erythema multiforme major (EMM) secondary to the influenza vaccine or Mycoplasma pneumoniae-induced rash and mucositis (MIRM).
View Article and Find Full Text PDFSuppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia.
PLoS Pathog
November 2024
Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Article Synopsis
- Mycoplasma pneumoniae is a key cause of pneumonia, and itaconate, produced by neutrophils, has been identified as a pro-inflammatory metabolite during infection.
- It was found that Irg1 knockout mice exhibited reduced bacterial load and inflammation compared to wild-type mice, indicating that Irg1 may worsen the infection.
- The study suggests that targeting the Irg1/itaconate pathway could be a new strategy for treating pneumonia caused by M. pneumoniae.
incidence, phenotype, and severity in children and adolescents in Denmark before, during, and after the COVID-19 pandemic: a nationwide multicentre population-based cohort study.
Lancet Reg Health Eur
December 2024
Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Denmark.
Background: infections resurged globally in 2023-2024 after a three-year decline during the COVID-19 pandemic. We explored the incidence and severity of infections in children and adolescents before, during, and after the pandemic.
Methods: This nationwide, population-based cohort study included all Danish children and adolescents aged 0-17 years with a positive PCR test from May 1, 2016, to April 30, 2024.
A comprehensive review of infection in chronic lung diseases: recent advances in understanding asthma, COPD, and bronchiectasis.
Front Med (Lausanne)
September 2024
Pediatrics, Shijiazhuang Second Hospital, Shijiazhuang, China.
Article Synopsis
- The review covers 30 years of research linking infections to chronic respiratory diseases like asthma, COPD, and bronchiectasis, particularly focusing on how infections contribute to these conditions.
- Recent findings show that infections increase the risk of asthma flare-ups and may lead to bronchiectasis in certain individuals.
- The article also discusses the immune system's role in chronic lung diseases, along with the challenges in diagnosing and treating these conditions while suggesting areas for future research.
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