Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpainsymman.2018.09.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Systematic review and meta-analysis of non-SCORTEN predictors of mortality in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Int J Dermatol
October 2024
School of Medicine, University of New South Wales, Kensington, NSW, Australia.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions with high in-hospital mortality rates, ranging from 12-49%, prompting a need for better mortality prognostication.
- This systematic review and meta-analysis examined factors that could predict mortality in SJS and TEN patients, focusing on predictors not included in the widely used SCORTEN scoring system.
- The study found that conditions like preexisting renal disease, renal and respiratory involvement, diabetes, sepsis, comorbidity, and delayed hospitalization significantly increased the risk of death in these patients, providing valuable insights for clinical assessment.
Role of neutrophil-lymphocyte ratio as a prognostic marker in SJS/TEN patients.
Arch Dermatol Res
August 2024
Department of Dermatology, Venereology and Leprosy, Father Muller Medical College, Mangalore, India.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions mainly triggered by drugs, and SCORTEN is used to predict their severity and mortality risk.
- A recent study sought to determine if the neutrophil-lymphocyte ratio (NLR) could serve as a prognostic marker for SJS/TEN by analyzing patient data over four years from a hospital.
- Although a weak positive correlation was found between NLR and SCORTEN, it wasn’t statistically significant, suggesting that while NLR indicates systemic inflammation, its effectiveness in predicting disease severity needs further research with more patients.
Prognostic significance of the systemic immune-inflammation index in patients with Steven-Johnson syndrome and toxic epidermal necrolysis.
Clin Exp Dermatol
December 2024
Division of Dermatology, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and eosinophil count are known prognostic indicators for the severity of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). This study explores the correlation of systemic immune-inflammation index (SII), platelet-lymphocyte ratio (PLR) and NLR with Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) and patient outcomes. A retrospective audit of 34 patients with SJS/TEN (25 SJS, 3 SJS/TEN overlap, 6 TEN) was conducted from 2018 to 2022.
View Article and Find Full Text PDFClinico- Therapeutic Study of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis and Prognostic Significance of SCORTEN in Indian Patients.
Indian J Dermatol
February 2024
From the Department of Dermatology, B.J. Medical College, Civil Hospital, Ahmedabad, Gujarat, India.
Background: Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening dermatological emergencies. SCORTEN (SCORe of toxic epidermal necrolysis) is a validated score to predict mortality; however, there is a paucity of data to determine its usefulness in the Indian population.
Objective: To evaluate the accuracy of SCORTEN as a prognostic marker in SJS-TEN.
RDW-SD and PCT Are Potential Prognostic Factors for In-hospital Death in Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
Allergy Asthma Immunol Res
November 2023
The Institute of Dermatology and Venereology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Purpose: Our study aimed to explore potential prognostic factors in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients from easily accessible laboratory data and to investigate whether the combination of these indicators with a score for toxic epidermal necrolysis (SCORTEN) can improve the predictive value.
Methods: Data from 85 SJS/TEN patients hospitalized from 2010 to 2021 were retrospectively analyzed. The primary outcome was in-hospital mortality.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!