We investigated the association between the triglycerides to high-density lipoprotein cholesterol (TG/HDL) ratio and low testosterone and sex hormone-binding globulin (SHBG) levels in middle-aged and elderly men. This cross-sectional study included 1055 men aged ≥45 years who underwent a medical examination. The cutoff points for low testosterone and SHBG levels were determined as 12.2 and 29.4 nmol/L, which corresponded to the 25th percentile of the current sample. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for low testosterone and SHBG levels were calculated after adjusting for confounding variables across TG/HDL ratio quartiles (Q1: ≤ 1.70, Q2: 1.71-2.54, Q3: 2.55-3.77, Q4: ≥3.78) using multiple logistic regression analysis. The proportion of subjects with low testosterone and SHBG levels significantly increased in accordance with TG/HDL ratio quartile. The ORs (95% CIs) of the lowest TG/HDL ratio quartile compared to the highest TG/HDL ratio quartile for low levels of testosterone and SHBG were 1.96 (1.13-2.75) and 3.90 (2.38-6.38), respectively, after adjusting for age, body mass index, smoking status, alcohol drinking, regular exercise, diastolic blood pressure, fasting plasma glucose, and total cholesterol level. The TG/HDL ratio was inversely associated with testosterone and SHBG levels in middle-aged and elderly Korean men.
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http://dx.doi.org/10.1080/13685538.2018.1501015 | DOI Listing |
Front Endocrinol (Lausanne)
January 2025
Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Introduction: The global burden of gout, a severe and painful arthralgia, is of note and is expected to increase in the future. We aimed to investigate the association between the triglyceride/high-density lipoprotein (TG/HDL) ratio, a simple and validated biomarker for insulin resistance, and the incidence of gout in a longitudinal setting in the general population.
Methods: Our study was conducted using the National Health Insurance Service-Health Screening Cohort database of Republic of Korea (2002-2019).
BMC Cardiovasc Disord
January 2025
Department of Cardiology, Northern Jiangsu People's Hospital, Nantong West Road No. 98, Yangzhou, Jiangsu, 225001, China.
Objectives: The aim of this study was to explore the correlation between blood test indicators and Atrial Fibrillation (AF) in Individuals Aged 65 and Older in Yangzhou, Jiangsu.
Methods: From January 1, 2019, to August 31, 2023, an epidemiological cross-sectional survey was conducted among the elderly population undergoing health check-ups at Northern Jiangsu People's Hospital in Jiangsu Province. Patients diagnosed with AF after a 12-lead electrocardiogram were included in the case group, and non-AF individuals matched by age and gender in a 1:4 frequency ratio were included in the control group.
Objectives: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality globally, influenced by a complex interplay of risk factors including lipid disorders and insulin resistance (IR). The triglyceride-glucose (TyG) index and the triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio have emerged as potential indicators for assessing cardiovascular risk. This study aimed to evaluate the predictive value of hypertriglyceridemia, the TyG index, and the TG/HDL ratio for mortality and CVD occurrence within an Iranian population.
View Article and Find Full Text PDFLipids Health Dis
January 2025
Dipartimento Di Scienze Mediche E Chirurgiche, Università Degli Studi Di Bologna, Bologna, Emilia-Romagna, Italy.
Background: Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributes to IR, while IR is a known predictor for the development of hyperuricemia. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker for IR. This research aimed to investigate the interaction between IR and glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk in a large population cohort study.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Department of Endocrinology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
Objective: Recent studies have underscored the metabolic and cardiovascular regulatory capacity of perirenal adipose tissue (PAT), implicating its potential involvement in the pathogenesis of left ventricular hypertrophy (LVH). This investigation aims to assess the relationship between increased PAT mass and LVH, while also examining the potential mediating role of insulin resistance in this relationship among individuals with type 2 diabetes mellitus (T2DM).
Method: 1112 individuals with T2DM were prospectively recruited for this study.
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