Humanity builds upon scientific findings, but the credibility of science might be at risk in a 'postfactual' era of advanced information technologies. Here we propose a systemic change for science, to turn away from a growth paradigm and to refocus on quality, characterized by curiosity, surprise, discovery, and societal relevance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tree.2018.08.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experienced Patients in Cameroon: Designing Future Treatment Strategies for Low- and Middle-Income Countries.
Viruses
January 2025
Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Islatravir (ISL) is a novel antiretroviral that inhibits HIV-1 reverse transcriptase translocation. The M184V mutation, known to reduce ISL's viral susceptibility in vitro, could arise from prolonged exposure to nucleoside reverse transcriptase inhibitors (NRTI) (3TC). This study evaluated the predictive efficacy of ISL and identified potentially active antiretrovirals in combination among treatment-experienced patients in Cameroon, where NRTIs (3TC) have been the backbone of ART for decades now.
View Article and Find Full Text PDFAn Explainable CNN and Vision Transformer-Based Approach for Real-Time Food Recognition.
Nutrients
January 2025
Department of Computer Engineering, Inje University, Gimhae 50834, Republic of Korea.
Background: Food image recognition, a crucial step in computational gastronomy, has diverse applications across nutritional platforms. Convolutional neural networks (CNNs) are widely used for this task due to their ability to capture hierarchical features. However, they struggle with long-range dependencies and global feature extraction, which are vital in distinguishing visually similar foods or images where the context of the whole dish is crucial, thus necessitating transformer architecture.
View Article and Find Full Text PDFShifting Focus to Quality: An Innovative Modeling Approach Includes Processing History for Rubber Part Quality Simulation.
Polymers (Basel)
January 2025
Department of Polymer Engineering and Science, Polymer Processing, Montanuniversitaet Leoben, Franz-Josef Strasse 18, 8700 Leoben, Austria.
An innovative modeling approach for the simulative description of the part quality of rubber materials, including the processing history, is presented in this paper. This modeling approach, the so-called average curing speed (ACS) model, is based on the degree of cure and the average curing speed instead of the conventionally considered temperature approach. Such approach neglects the processing history by calculating only the degree of cure.
View Article and Find Full Text PDFExploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3'-Processing Suppression.
Pharmaceuticals (Basel)
December 2024
Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai 410206, Maharashtra, India.
: The global AIDS pandemic highlights the urgent need for novel antiretroviral therapies (ART). In our previous work, Zinc C295 was identified as a potent HIV-1 integrase strand transfer (ST) inhibitor. This study explores its potential to also inhibit 3'-processing (3'P), thereby establishing its dual-targeting capability.
View Article and Find Full Text PDFThe Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection.
Pathogens
December 2024
State Research Center of Virology and Biotechnology "Vector", Koltsovo 630559, Russia.
Human Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident lymphoid and monocytic cells, and glial cells of the central nervous system. The importance of studying the properties of proviral reservoirs is connected with the inaccessibility of integrated HIV proviral DNA for modern anti-retroviral therapies (ARTs) that block virus reproduction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!