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Phosphate Binder Impairs Levothyroxine Absorption in a Hypothyroid Patient With End-Stage Renal Disease.
Cureus
October 2024
Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA.
End-stage renal disease (ESRD) patients have an increased incidence of hypothyroidism, and those with serum thyroid stimulating hormone (TSH) levels above the reference range have excess mortality, increased cardiovascular disease, impaired health-related quality of life, and altered body composition. We report a patient with ESRD on chronic hemodialysis and Hashimoto's disease, who is on chronic levothyroxine therapy. Despite a high levothyroxine dose of 2.
View Article and Find Full Text PDFREMEDIAL INTERVENTION OF FERTILITY AGENT AND GENE 35 ON INDUCED CYSTIC OVARY IN RATS.
Georgian Med News
October 2024
3Almaaqal University, College of Pharmacy, Iraq.
Infertility is a condition with a negative health state and cystic ovary disorder is one of it is causes. PCOS is a prevalent derange till now. Therefore, current study is designed to estimate the role of Gene 35 and fertility supplements (composed from chasteberry, green tea extracts and L-arginine along with some elements),as alternative therapy for induced cystic ovary with letrozole in rats.
View Article and Find Full Text PDFRole of DNA damage response in cyclophosphamide-induced premature ovarian failure in mice.
J Obstet Gynaecol Res
September 2024
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Article Synopsis
- The study aimed to explore the DNA damage response (DDR) in mice undergoing premature ovarian failure (POF) induced by cyclophosphamide (CTX).
- The results showed that CTX treatment led to decreased body and ovarian weights, irregular estrus cycles, and hormonal changes, indicating significant ovarian dysfunction in the POF model.
- The findings suggest that CTX-induced POF in mice is linked to the activation of the DDR pathway involving ATM, P53, and P21, highlighting the potential mechanisms behind ovarian failure.
Ameliorative mechanism of dietary vitamin d and magnesium on newborn's pulmonary toxicity induced by cadmium.
J Trace Elem Med Biol
July 2024
Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran.
Cadmium (Cd) exposure in mothers can cause respiratory issues in newborns, but the exact toxicity mechanisms are not fully understood. Vitamin D deficiency in Cd-exposed rats is associated with increased cadmium accumulation in tissues. Finding a cost-effective medication that is vital for the body while also reducing the effects of poisoning is crucial in treating poisonings.
View Article and Find Full Text PDFRole of C-Reactive Protein and Erythrocyte Sedimentation Rate in the Diagnosis and Monitoring of Treatment Response in Treatment Naïve Subjects with Chronic Pulmonary Aspergillosis.
Mycopathologia
October 2023
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Sector-12, Chandigarh, 160012, India.
Article Synopsis
- - The study investigates how effective C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are for diagnosing chronic pulmonary aspergillosis (CPA) in patients.
- - Researchers analyzed data from 434 CPA patients and 20 controls, finding that both CRP and ESR had low sensitivity and specific results, indicating they are not reliable diagnostic tools.
- - After treatment, results showed that while ESR and CRP levels decreased or remained stable in about 60% of patients, they actually increased in roughly 40%, further highlighting their limited usefulness in monitoring CPA.
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