AI Article Synopsis
- - The study compared the effectiveness and costs of four treatments for large tympanic membrane perforations (TMPs): ofloxacin drops (OFLX), gelatin sponge patches, spontaneous healing, and endoscopic myringoplasty, involving 100 patients.
- - Results showed that OFLX had the highest closure rate (95.7%) and shortest average closure time (about 13.7 days), while endoscopic myringoplasty was the most expensive option with significant costs of $715.90.
- - Although both gelatin sponge and myringoplasty improved closure times compared to spontaneous healing, they didn't show better closure rates, and gelatin sponge treatments had higher costs without significant benefits over OFLX or spontaneous healing.
Article Abstract
Objective: We investigated the medical costs and effects of ofloxacin drops (OFLX), gelatin sponge patches, spontaneous healing, and endoscopic myringoplasty on healing in large tympanic membrane perforations (TMPs).
Methods: In total, 100 patients with large traumatic TMPs involving >50% of the eardrum were randomly assigned to OFLX, gelatin sponge, spontaneous healing, or endoscopic myringoplasty treatment groups. Medical costs, closure times, and closure rates were compared among groups at 6 months.
Results: The closure rates in the OFLX, gelatin sponge, spontaneous healing, and endoscopic myringoplasty groups were 95.7%, 82.6%, 58.3%, and 91.7%, respectively (P = 0.05). The mean closure time was 13.73 ± 6.14 days in the OFLX group, 15.89 ± 4.95 days in the gelatin sponge group, 48.36 ± 10.37 days in the spontaneous healing group, and 12 days in the endoscopic myringoplasty group (P < 0.001). The mean medical costs in US dollars were $15.53 ± 3.15, $103.64 ± 111.58, $11.17 ± 1.33, and $715.90 in the OFLX, gelatin sponge, spontaneous healing, and endoscopic myringoplasty groups, respectively (P < 0.001).
Conclusion: Although the gelatin sponge and myringoplasty treatments significantly shortened the closure time compared with spontaneous healing, the gelatin sponge patch did not significantly improve the closure rate, and the medical cost of myringoplasty was significantly higher than that of the other treatments. In contrast, OFLX significantly shortened closure time and had a higher closure rate than spontaneous healing, and the medical costs were lower than those of the gelatin sponge and myringoplasty procedures.
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| http://dx.doi.org/10.1016/j.amjoto.2018.08.007 | DOI Listing |
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