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Prevalence of persistent SARS-CoV-2 in a large community surveillance study.
Nature
February 2024
Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Article Synopsis
- * Those with persistent infections were found to have over 50% higher odds of experiencing long COVID symptoms compared to those without persistent infections.
- * The research reveals viral mutations associated with these persistent infections, suggesting ongoing viral evolution and potential impacts on treatment and vaccine effectiveness.
Lineage replacement and evolution captured by 3 years of the United Kingdom Coronavirus (COVID-19) Infection Survey.
Proc Biol Sci
October 2023
Big Data Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK.
The Office for National Statistics Coronavirus (COVID-19) Infection Survey (ONS-CIS) is the largest surveillance study of SARS-CoV-2 positivity in the community, and collected data on the United Kingdom (UK) epidemic from April 2020 until March 2023 before being paused. Here, we report on the epidemiological and evolutionary dynamics of SARS-CoV-2 determined by analysing the sequenced samples collected by the ONS-CIS during this period. We observed a series of sweeps or partial sweeps, with each sweeping lineage having a distinct growth advantage compared to their predecessors, although this was also accompanied by a gradual fall in average viral burdens from June 2021 to March 2023.
View Article and Find Full Text PDFFirst Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment.
Phys Rev Lett
July 2023
University of Califonia, Los Angeles, Department of Physics and Astronomy, Los Angeles, California 90095-1547.
The LUX-ZEPLIN experiment is a dark matter detector centered on a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility in Lead, South Dakota, USA. This Letter reports results from LUX-ZEPLIN's first search for weakly interacting massive particles (WIMPs) with an exposure of 60 live days using a fiducial mass of 5.5 t.
View Article and Find Full Text PDFCOVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK.
Sci Rep
May 2023
Health Economics Research Centre, Richard Doll Building, Old Road Campus, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Article Synopsis
- Vaccination against COVID-19 has clear physiological benefits, but its impact on behavior is less understood, particularly regarding risk compensation, where people take on more risk due to feeling safer.
- The study found that while personal vaccination didn't significantly change individual behaviors, people were more likely to engage in riskier activities as overall vaccination rates in the population increased.
- This trend of risk compensation was consistent across the four nations of the UK, each having different policies in place during the vaccination rollout.
Hyperventilation in functional seizures: Evidence for subtypes.
Seizure
July 2022
Department of Psychiatry, University of Melbourne, Austin Health, 145 Studley Road, LTB10, Heidelberg, VIC 3084, Australia.
Article Synopsis
- The study focuses on functional seizures (FS), particularly a subtype triggered by hyperventilation, to explore whether this indicates different seizure mechanisms.
- Researchers analyzed video-EEG/ECG data from 120 patients, identifying 11 cases where seizures were hyperventilation-induced.
- Findings revealed two distinct heart rate patterns before seizures: one group had a higher baseline heart rate that increased prior to the seizure, while the other group exhibited a lower baseline with no pre-seizure increase, suggesting different underlying mechanisms for FS.
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