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Widening access to isotretinoin in primary care: an evaluation of New Zealand national dispensing data for isotretinoin for acne, 2008-2023.
BMJ Open
January 2025
General Practice and Primary Health Care, The University of Auckland Faculty of Medical and Health Sciences, Auckland, New Zealand
Objectives: To identify what changes in the prescribing of isotretinoin have occurred since funded prescriber access was widened in 2009 from 'dermatologist only' prescribing to include 'general practitioners (GPs) and nurse practitioners working within their scope of practice'.
Design: Evaluation of isotretinoin dispensing data from 2008 to 2023 using the national annual prescribing data obtained from the New Zealand Pharmaceutical National Collection database.
Setting: All New Zealand citizens prescribed and dispensed funded isotretinoin for acne from 2008 to 2023 were included.
Highly sensitive fluorescent aptasensor based on magnetic metal-organic framework for aflatoxin B1 detection.
Talanta
January 2025
Engineering Research Center of Grain Storage and Security of Ministry of Education, Henan Provincial Engineering Technology Research Center on Grain Post Harvest, School of Food and Strategic Reserves, Henan University of Technology, Lianhua Road 100, Zhengzhou High-Tech Development Zone, Zhengzhou, 450001, Henan, China. Electronic address:
Aflatoxin B1 (AFB1) has strong carcinogenicity, mutagenicity, and teratogenicity even at low concentrations, presenting a major risk to food safety and human health, hence, it is crucial to develop a sensitive detection technique for AFB1. Consequently, cadmium telluride (CdTe) quantum dots conjugated with AFB1 aptamers serve as fluorescent signal probes, whereas FeO@UiO-66-NH nanocomplexes are employed as magnetic carriers and fluorescence quenchers. FeO@UiO-66-NH reduces background signal interference, thereby enhancing detection sensitivity and Förster Resonance Energy Transfer (FRET) efficiency.
View Article and Find Full Text PDFThe concentration of malachite green in fish: a systematic review, meta-analysis, and probabilistic risk assessment.
Int J Environ Health Res
January 2025
Faculty of Biotechnologies (BioTech), ITMO University, Saint Petersburg, Russia.
Malachite Green (MG) is an antibiotic with antifungal activity, which is illegal to use in agriculture due to its mutagenic and teratogenic properties. Several scientific papers have been published on MG in fish. Therefore, an attempt was made to determine the meta-analysis concentration of MG in fish based on countries and types of fish subgroups, as well as the health risks of consumers, using the Monte Carlo simulation (MCS) model.
View Article and Find Full Text PDFIs lamotrigine a teratogen?
Seizure
January 2025
Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD, 4027, Australia. Electronic address:
Aim: To assess whether lamotrigine (Lamictal), when used in antiseizure medication (ASM) monotherapy, is a teratogen.
Materials/methods: Analysis of data from 490 LTG monotherapy treated pregnancies and 214 pregnancies in women with epilepsy not exposed to any antiseizure medications during at least the first half of pregnancy.
Results: The LTG-treated and the untreated pregnancies were well matched in nearly all regards apart from ASM exposure.
Extract Can Be Used as a Raw Material Source for a Sterility Agent for .
Biology (Basel)
January 2025
Hunan Engineering Research Center of Ecological Environment Intelligent Monitoring and Disaster Prevention and Mitigation Technology in Dongting Lake Region, College of Information and Electronic Engineering, Hunan City University, Yiyang 413000, China.
Plant sterilants are used to control rodent populations due to their minimal environmental risk and other ethical considerations. However, their practical utilization is unsatisfactory due to high costs and processing difficulties. is a plant material that has shown the potential to inhibit the reproduction of , a species that causes serious damage to crops in the Dongting Lake region in China.
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