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BiomiX, a user-friendly bioinformatic tool for democratized analysis and integration of multiomics data.
BMC Bioinformatics
January 2025
LBAI, UMR1227, Univ Brest, Inserm, Laboratory of Immunology, CHU Brest, Brest, France.
Background: Interpreting biological system changes requires interpreting vast amounts of multi-omics data. While user-friendly tools exist for single-omics analysis, integrating multiple omics still requires bioinformatics expertise, limiting accessibility for the broader scientific community.
Results: BiomiX tackles the bottleneck in high-throughput omics data analysis, enabling efficient and integrated analysis of multiomics data obtained from two cohorts.
Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia.
Alzheimers Res Ther
January 2025
Laboratory for Clinical Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Crta M40, km38, Madrid, 28223, Spain.
Background: Dementia patients commonly present multiple neuropathologies, worsening cognitive function, yet structural neuroimaging signatures of dementia have not been positioned in the context of combined pathology. In this study, we implemented an MRI voxel-based approach to explore combined and independent effects of dementia pathologies on grey and white matter structural changes.
Methods: In 91 amnestic dementia patients with post-mortem brain donation, grey matter density and white matter hyperintensity (WMH) burdens were obtained from pre-mortem MRI and analyzed in relation to Alzheimer's, vascular, Lewy body, TDP-43, and hippocampal sclerosis (HS) pathologies.
Publisher Correction: Uniaxial strain tuning of charge modulation and singularity in a kagome superconductor.
Nat Commun
January 2025
Physik-Institut, Universität Zürich, Zürich, Switzerland.
Author Correction: Ligand-tuning copper in coordination polymers for efficient electrochemical C-C coupling.
Nat Commun
January 2025
School of Chemical and Biomolecular Engineering and The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, Australia.
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