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Combined effect of bacteriophage and antibiotic on the inhibition of the development of antibiotic resistance in . | LitMetric

Combined effect of bacteriophage and antibiotic on the inhibition of the development of antibiotic resistance in .

Food Sci Biotechnol

2Department of Medical Biomaterials Engineering and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341 Republic of Korea.

Published: August 2018

This study was designed to evaluate the combined effects of bacteriophage and antibiotic on the reduction of the development of antibiotic-resistance in LT2. The susceptibilities of to ciprofloxacin and erythromycin were increased when treated with bacteriophages, showing more than 10% increase in clear zone sizes and greater than twofold decrease in minimum inhibitory concentration values. The growth of was effectively inhibited by the combination of bacteriophage P22 and ciprofloxacin. The combination treatment effectively reduced the development of antibiotic resistance in . The relative expression levels of efflux pump-related genes (, , and ) and outer membrane-related genes (, , and ) were decreased at all treatments. This study provides useful information for designing new antibiotic therapy to control antibiotic-resistant bacteria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085247PMC
http://dx.doi.org/10.1007/s10068-018-0351-zDOI Listing

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