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Adipogenesis inhibitory effects of in mouse bone marrow stromal D1 cells. | LitMetric

Adipogenesis inhibitory effects of in mouse bone marrow stromal D1 cells.

Food Sci Biotechnol

1Department of Food and Nutrition, College of Medical and Life Sciences, Silla University, Busan, 46958 Korea.

Published: March 2016

AI Article Synopsis

Article Abstract

Unbalanced differentiation of bone marrow cells into adipocytes rather than osteoblasts causes severe bone-related disorders, such as osteoporosis. Natural products that can act against unbalanced differentiation are targeted for development of functional dietary supplements. , a halophyte known for anti-oxidant constituents, was studied for beneficial effects in prevention of adipogenesis of bone marrow stromal D1 cells . Solvent-partitioned extract fractions of prevented differentiating D1 cells from accumulating lipids. Expression of the key adipogenic markers PPARγ, SREBP1c, and C/EBPα were inhibited at mRNA and protein levels. Suppressed protein levels of the phosphorylated MAPK-related factors ERK, JNK, and p-38 indicated inhibition of PPARγ pathway-linked adipogenesis in D1 cells. The n-BuOH fraction was the most effective fraction for bioactive substances. inhibited adipogenesis in D1 bone marrow stromal cells due to the presence of bioactive flavonoids.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049418PMC
http://dx.doi.org/10.1007/s10068-016-0109-4DOI Listing

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