The present study is aimed to prepare κ-carrageenan microparticles for the encapsulation of model drug, coenzyme Q10 (CoQ10). A face-centered central composite design was employed to study the effects of three different formulation variables (κ-carrageenan, emulsifier, and oil). The powder yield was found inversely affected by the κ-carrageenan and oil concentration. The encapsulation efficiency was maximized in the region of the middle level κ-carrageenan concentration, the high level emulsifier concentration, and the low level oil concentration. The emulsifier concentration was the most influential variable on the particle size of powder. The optimal formulation was reported as 0.91% (w/v) κ-carrageenan concentration, 0.64% (w/v) emulsifier, and 1.0% (w/w) oil. Both differential scanning colorimeter and X-ray diffraction analyses proved that incorporation of CoQ10 into κ- carrageenan microcapsules resulted in amorphous powder with significantly (<0.05) higher water solubility compared to pure CoQ10 and physical mixture in the crystalline form.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049400 | PMC |
| http://dx.doi.org/10.1007/s10068-016-0098-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Psoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis.
Eur J Pharm Sci
December 2024
College of Pharmacy and Medical Technology, Putian University, Putian 351100, Fujian, China; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Putian 351100, Fujian, China.
Blue light will be a promising alternative for photodynamic therapy in psoriasis, but the photosensitizer in vivo remains unexplored. Mesoporous zinc phosphate microparticle (MZP) was synthesized successfully in this study, as evidenced by XPS, XRD, and nitrogen adsorption experiments. Its psoriatic skin-sensitive property was corroborated by SEM and the higher cumulative release rate of that impregnated with curcumin (Cur) and glycyrrhizic acid (GA), namely Cur-GA-MZP, at pH 5.
View Article and Find Full Text PDFDesign and engineering of microenvironments of supported catalysts toward more efficient chemical synthesis.
Adv Colloid Interface Sci
December 2024
Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China. Electronic address:
Catalytic species such as molecular catalysts and metal catalysts are commonly attached to varieties of supports to simplify their separation and recovery and accommodate various reaction conditions. The physicochemical microenvironments surrounding catalytic species play an important role in catalytic performance, and the rational design and engineering of microenvironments can achieve more efficient chemical synthesis, leading to greener and more sustainable catalysis. In this review, we highlight recent works addressing the topic of the design and engineering of microenvironments of supported catalysts, including supported molecular catalysts and supported metal catalysts.
View Article and Find Full Text PDFMicroparticle disease in hip prostheses: A case report.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
December 2024
Hospital Universitario de Bellvitge, L' Hospitalet de Llobregat, Barcelona, Spain.
Microencapsulation of by Emulsion Technique and Evaluation of Microparticle Properties and Bacterial Viability Under Storage, Processing, and Digestive System Conditions.
Food Sci Nutr
December 2024
Department of Food Science and Technology, Faculty of Agriculture Ferdowsi University of Mashhad Mashhad Iran.
In this research, the emulsification method was used to encapsulate in microparticles of whey protein concentrate (WPC) at different levels (1%, 2%, and 4%) and gum Arabic (GA) at three levels (0/5%, 1%, and 1/5%) and a constant level of sunflower oil (5%). The results showed that emulsions with higher quantities of wall materials exhibited better encapsulation efficiency (67%/57%) and preservation ability at different temperatures, different pH, and presence of 1% bile salt. During the storage time, the droplet size of the emulsion increased more than two times (from 2.
View Article and Find Full Text PDFNovel double-layered PLGA microparticles-dissolving microneedle (MPs-DMN) system for peptide drugs sustained release by transdermal delivery.
Int J Pharm
December 2024
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; Beijing CAS Microneedle Technology Ltd., Beijing 102609, China. Electronic address:
The combination of microparticles (MPs) with dissolving microneedles (DMN) represents a promising transdermal approach for the sustained release of biomacromolecule drug. In this study, we developed a double-layered microparticles-dissolving microneedle (MPs-DMN) system, which strategically concentrates PLGA MPs at the tip of the microneedle to achieve sustained release of peptide drugs through transdermal delivery. We selected exenatide (EXT) as a model peptide drug and established HPLC-UV and UPLC-MS methods for the quantitative analysis of the drug content of MPs-DMN and drug concentrations in plasma.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!