Influence of water-soluble extracts of long-term fermented on bone metabolism bioactivity and breast cancer suppression.

Anti-cancer effects of extracts are usually studied based on methanol extraction focusing on isoflavones, the principal extracted components. In this syudy, effects of water-soluble extracts of long-term fermented containing water-soluble low Mw peptides produced by microorganisms were studied. extracts had effects which arrested the cell cycle, inhibited proliferation, and caused consequential apoptosis in breast cancer cells. water-soluble extracts increased bone density via activation of osteoblast differentiation and suppression of osteoclast differentiation. Effects increased as the fermentation period extended because the fermentation period influenced extract contents. The value and utility of as a functional food should be considered.