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Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease. | LitMetric

AI Article Synopsis

Article Abstract

Differences in lung anatomy between mice and humans, as well as frequently disappointing results when using animal models for drug discovery, emphasise the unmet need for models that can complement animal studies and improve our understanding of human lung physiology, regeneration and disease. Recent papers have highlighted the use of three-dimensional organoids and organs-on-a-chip to mimic tissue morphogenesis and function Here, we focus on the respiratory system and provide an overview of these models, which can be derived from primary lung cells and pluripotent stem cells, as well as healthy or diseased lungs. We emphasise their potential application in studies of respiratory development, regeneration and disease modelling.

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http://dx.doi.org/10.1183/13993003.00876-2018DOI Listing

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