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Flexible progestin-primed ovarian stimulation versus a GnRH antagonist protocol in predicted suboptimal responders undergoing freeze-all cycles: a randomized non-inferiority trial.
Hum Reprod
December 2024
Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China.
Study Question: Are live birth rates (LBRs) per woman following flexible progestin-primed ovarian stimulation (fPPOS) treatment non-inferior to LBRs per woman following the conventional GnRH-antagonist protocol in expected suboptimal responders undergoing freeze-all cycles in assisted reproduction treatment?
Summary Answer: In women expected to have a suboptimal response, the 12-month likelihood of live birth with the fPPOS treatment did not achieve the non-inferiority criteria when compared to the standard GnRH antagonist protocol for IVF/ICSI treatment with a freeze-all strategy.
What Is Known Already: The standard PPOS protocol is effective for ovarian stimulation, where medroxyprogesterone acetate (MPA) is conventionally administered in the early follicular phase for ovulatory suppression. Recent retrospective cohort studies on donor cycles have shown the potential to prevent premature ovulation and maintain oocyte yields by delaying the administration of MPA until the midcycle (referred to as fPPOS), similar to GnRH antagonist injections.
Optimization of a Web-Based Self-Assessment Tool for Preconception Health in People of Reproductive Age in Australia: User Feedback and User-Experience Testing Study.
JMIR Hum Factors
December 2024
Faculty of Medicine and Health, The University of Sydney, Susan Wakil Health Building, Western Avenue, Camperdown, 2050, Australia, 61 422-259-194.
Background: Good preconception health reduces the incidence of preventable morbidity and mortality for women, their babies, and future generations. In Australia, there is a need to increase health literacy and awareness about the importance of good preconception health. Digital health tools are a possible enabler to increase this awareness at a population level.
View Article and Find Full Text PDFThe Role of Hispanic Women's Marital Status on Intimate Partner Violence and Reproductive Coercion Resulting in Unintended Pregnancy.
J Interpers Violence
December 2024
Texas Woman's University, Dallas, TX, USA.
The present study investigates the impact of Hispanic women's marital status on the occurrence of intimate partner violence (IPV) and reproductive coercion (RC), resulting in unintended pregnancy (UIP). This is a significant public health concern as prior research has shown Hispanic women are disproportionately affected by UIP more than non-Hispanic White women. Data were drawn from the 2018 to 2020 Pregnancy Risk Assessment Monitoring System dataset of Hispanic women ( = 3,725) who have just given birth within the last 9 months and responded to all relevant survey items.
View Article and Find Full Text PDFAssociation of preconception premenstrual disorders with perinatal depression: an analysis of the perinatal clinical database of a single Japanese institution.
Biopsychosoc Med
December 2024
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan.
Background: Recent studies have identified premenstrual disorders (PMDs) as a risk factor for postpartum depression. However, routine screening for preconception PMDs is not yet common in Japan. This study investigated the association between preconception PMDs and perinatal depression in a single tertiary care setting.
View Article and Find Full Text PDFPredicting cardiac and pregnancy outcomes in women with adult congenital heart disease using the Anatomic and Physiological (AP) Classification System: How much does physiology matter?
Int J Cardiol Congenit Heart Dis
March 2024
University of Sydney, Sydney Medical School, Sydney, New South Wales, Australia.
Background: Pregnancy in women with congenital heart disease (CHD) is associated with an increased risk of adverse maternal and fetal events. Despite the physiological impact of CHD on pregnancy, current risk stratification scores primarily consider anatomical lesions. We assessed the performance of the novel American Heart Association Anatomic and Physiological (AP) classification system in predicting adverse maternal cardiac, obstetric and fetal events, and compared it with established risk models.
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