AI Article Synopsis
- Researchers aim to understand Parkinson's disease (PD) pathology, noting that only about 10% of patients have identified genetic mutations, indicating it's a multifactorial disorder.
- Recent studies highlight the role of epigenetics, such as changes in miRNA expression, histone modification, and DNA methylation, in the development of PD.
- Analysis of methylation levels in specific PD-related genes across different brain regions revealed fluctuations that may influence gene expression through alterations in Sp1 binding.
Article Abstract
Efforts have been made to understand the pathophysiology of Parkinson's disease (PD). A significant number of studies have focused on genetics, despite the fact that the described pathogenic mutations have been observed only in around 10% of patients; this observation supports the fact that PD is a multifactorial disorder. Lately, differences in miRNA expression, histone modification, and DNA methylation levels have been described, highlighting the importance of epigenetic factors in PD etiology. Taking all this into consideration, we hypothesized that an alteration in the level of methylation in PD-related genes could be related to disease pathogenesis, possibly due to alterations in gene expression. After analysing promoter regions of five PD-related genes in three brain regions by pyrosequencing, we observed some differences in DNA methylation levels (hypo and hypermethylation) in in some CpG dinucleotides that, possibly through an alteration in Sp1 binding, could alter their expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210421 | PMC |
| http://dx.doi.org/10.3390/cells7100150 | DOI Listing |
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