Polysaccharides protein complex offers a green alternative to synthetic polymers in the drug delivery system. Sericin (SC), a natural protein, in combination with rice bran albumin (RBA) and gellan gum (GG) forms a green based protein polysaccharide complex. The sericin functionalized gellan gum-rice bran (SC-GG-RBA) nanocomposites were characterized by different characterization techniques. It shows their prominent ability in balancing the biocompatibility, stability, biodegradability, and functionality of nanocarriers. The nanocomposites exhibited spherical shape with core protein-polysaccharide structures, and the average size was about 218 nm. High amount of Doxorubicin (DOX) was encapsulated into SC-GG-RBA nanocomposites in order to investigate the effective drug release in acidic tumor environment. DOX of 84% was released in vitro condition after 120 h in pH 4.0. DOX loaded green nanocomposites shows IC 5 μg/mL which was very low compared to free DOX of 9 μg/mL after treatment with MCF-7 cells. Only 42% of cells were survived after treatment with green nanocomposites. This was due to the effective uptake of nanomaterial by cancer cells and direct release of DOX in cytoplasmic region. Such high performance green nanocomposites have great potential in expanding the utilization of biomaterial from natural resources and development of sensible application in biomedical field.
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