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Understanding recent advances in non-amyloid/non-tau (NANT) biomarkers and therapeutic targets in Alzheimer's disease.
Alzheimers Dement (N Y)
November 2024
Alzheimer's Association Chicago Illinois USA.
Unlabelled: The Alzheimer's disease (AD) research community continues to make great strides in expanding approaches for early detection and treatment of the disease, including recent advances in our understanding of fundamental AD pathophysiology beyond the classical targets: beta-amyloid and tau. Recent clinical trial readouts implicate a variety of non-amyloid/non-tau (NANT) approaches that show promise in slowing cognitive decline for people with AD. The Alzheimer's Association Research Roundtable (AARR) meeting held on December 13-14, 2022, reviewed the current state of NANT targets on underlying AD pathophysiology and their contribution to cognitive decline, the current data on a diverse range of NANT biomarkers and therapeutic targets, and the integration of NANT concepts in clinical trial designs.
View Article and Find Full Text PDFAlzheimer's disease drug development in an evolving therapeutic landscape.
Alzheimers Dement (N Y)
November 2024
Alzheimer's Association Chicago Illinois USA.
Unlabelled: The Alzheimer's disease (AD) research field has entered a new era, where our fundamental understanding of the pathophysiology of AD and advances in biomarkers have not only allowed for earlier, timely, and accurate detection and diagnosis of the disease, but that amyloid removal has been shown to be associated with signals of slowing cognitive and functional decline. Although recent FDA-approved amyloid plaque-lowering monoclonal antibody therapies have shifted the trajectory of AD, additional treatment options will be key to further slowing clinical decline or stopping disease progression. Thus, new and emerging therapies for AD have created an evolving therapeutic landscape.
View Article and Find Full Text PDF[Delphi-Study: Evaluation of the new job profile "Chief Digital Officer" in German hospitals].
Z Evid Fortbild Qual Gesundhwes
December 2024
Purpose:Health e.V. Dortmund, Deutschland, APOLLON Hochschule der Gesundheitswirtschaft GmbH, Bremen, Deutschland. Electronic address:
Introduction: The main objective of the present study was to analyze the new job profile "Chief Digital Officer (CDO) in German hospitals". Here, best practices for the introduction of the job profile should be determined and the need for a CDO position to execute the digital transformation should be evaluated.
Methods: A standardized three-stage online Delphi process (expert consensus finding) followed by a roundtable discussion was performed, including 16 experts.
Weather and Marine Aquaculture Workers' Safety in Atlantic Canada.
J Agromedicine
December 2024
Department of Geography, Memorial University of Newfoundland, St. John's, NL, Canada.
Objective: Marine aquaculture workers are at high risk of injury and fatalities. Understanding the role of weather in occupational safety and health (OSH) in marine aquaculture is important for work design, planning, and for safety management and hazard reduction, but there is limited research on this subject.
Methods: Using findings from a review of research and grey literature and from key informant interviews and roundtable discussions in Atlantic Canada, this paper explores the impact of weather-driven hazards on marine aquaculture in Northern and temperate regions, along with the strategies employed to mitigate these impacts.
Medical trauma in young adults with inflammatory bowel disease: The role of trauma-informed care.
Health Care Transit
January 2024
Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, United States.
Medical trauma is a profound concern for those with chronic conditions like inflammatory bowel disease (IBD), especially young adults. This trauma, arising from both the disease itself and necessary medical interventions, manifests as an accumulation of traumatic experiences impacting a patient's physical and psychological well-being. The Crohn's and Colitis Young Adults Network (CCYAN) conducted a roundtable discussion involving young adult IBD patients and healthcare professionals focused on medical trauma and its implications in the treatment of young adults with IBD.
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