Blepharospasm in Japan: A Clinical Observational Study From a Large Referral Hospital in Tokyo.

Neuroophthalmology

Division of Neuro-ophthalmology, Inouye Eye Hospital, Tokyo, Japan.

Published: October 2018

Focal dystonia is regarded as a characteristic feature of blepharospasm. However, patients do not always present with motor symptoms. To clarify the clinical features of blepharospasm in Japan, we conducted a retrospective observational study involving a large population of patients from a single institution. Common symptoms included difficulty opening the eyes, photophobia, and ocular pain/irritation. Initial symptoms often occurred following the long-term use of psychotropics such as etizoram, benzodiazepines, and zolpidem (32% of patients). Our findings demonstrated that the clinical presentation of blepharospasm is heterogenous, and that understanding regarding sensory-dominant forms of the disease may be poor among practitioners in Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152494PMC
http://dx.doi.org/10.1080/01658107.2017.1409770DOI Listing

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