Focal dystonia is regarded as a characteristic feature of blepharospasm. However, patients do not always present with motor symptoms. To clarify the clinical features of blepharospasm in Japan, we conducted a retrospective observational study involving a large population of patients from a single institution. Common symptoms included difficulty opening the eyes, photophobia, and ocular pain/irritation. Initial symptoms often occurred following the long-term use of psychotropics such as etizoram, benzodiazepines, and zolpidem (32% of patients). Our findings demonstrated that the clinical presentation of blepharospasm is heterogenous, and that understanding regarding sensory-dominant forms of the disease may be poor among practitioners in Japan.
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http://dx.doi.org/10.1080/01658107.2017.1409770 | DOI Listing |
J Evid Based Med
September 2024
Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
Cureus
August 2024
Neurosurgery, Hyogo Medical University, Nishinomiya, JPN.
Background Meige syndrome is a segmental dystonia affecting the head and neck, with bilateral blepharospasm as the primary symptom. First-line treatment typically involves Botox injections. For cases resistant to this treatment, bilateral deep brain stimulation of the globus pallidus internus (GPi) is considered.
View Article and Find Full Text PDFTremor Other Hyperkinet Mov (N Y)
January 2024
Department of Neurosurgery, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
Background: Tourette syndrome (TS) is a neurologic condition characterized by motor and phonic tics. Dystonic tics, including blepharospasm, are considered atypical or unusual in severe TS.
Case Report: We report a severe case of TS with facial dystonic tics resembling blepharospasm in which the microlesion effect and a sustained therapeutic effect was observed with bilateral globus pallidus interna (GPi) deep brain stimulation (DBS).
Sci Rep
June 2023
Department of Ophthalmology, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Smart eyeglasses with an integrated electrooculogram (EOG) device (JINS MEME ES_R, JINS Inc.) were evaluated as a quantitative diagnostic tool for blepharospasm. Participants without blepharospasm (n = 21) and patients with blepharospasm (n = 19) undertook two voluntary blinking tests (light and fast) while wearing the smart eyeglasses.
View Article and Find Full Text PDFFront Neurosci
May 2023
Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Beijing, China.
Introduction: Meige syndrome (MS) is an adult-onset segmental dystonia disease, mainly manifested as blepharospasm and involuntary movement caused by dystonic dysfunction of the oromandibular muscles. The changes of brain activity, perfusion and neurovascular coupling in patients with Meige syndrome are hitherto unknown.
Methods: Twenty-five MS patients and thirty age- and sex-matched healthy controls (HC) were prospectively recruited in this study.
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