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| http://dx.doi.org/10.3389/fnsys.2018.00045 | DOI Listing |
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ESAT-6 protein suppresses allograft rejection by inducing CD4Foxp3 regulatory T cells through IκBα/cRel pathway.
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Section of Immunology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Background: Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppressive drugs. The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells.
View Article and Find Full Text PDFIntegrating finite element analysis in total hip arthroplasty for childhood hip disorders: Enhancing precision and outcomes.
World J Orthop
January 2025
Undip Biomechanics Engineering and Research Centre, Universitas Diponegoro, Semarang 50275, Central Java, Indonesia.
Total hip arthroplasty for adults with sequelae from childhood hip disorders poses significant challenges due to altered anatomy. The paper published by Oommen reviews the essential management strategies for these complex cases. This article explores the integration of finite element analysis (FEA) to enhance surgical precision and outcomes.
View Article and Find Full Text PDFBolstered bone regeneration by multiscale customized magnesium scaffolds with hierarchical structures and tempered degradation.
Bioact Mater
April 2025
Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
Addressing irregular bone defects is a formidable clinical challenge, as traditional scaffolds frequently fail to meet the complex requirements of bone regeneration, resulting in suboptimal healing. This study introduces a novel 3D-printed magnesium scaffold with hierarchical structure (macro-, meso-, and nano-scales) and tempered degradation (microscale), intricately customized at multiple scales to bolster bone regeneration according to patient-specific needs. For the hierarchical structure, at the macroscale, it can feature anatomic geometries for seamless integration with the bone defect; The mesoscale pores are devised with optimized curvature and size, providing an adequate mechanical response as well as promoting cellular proliferation and vascularization, essential for natural bone mimicry; The nanoscale textured surface is enriched with a layered double hydroxide membrane, augmenting bioactivity and osteointegration.
View Article and Find Full Text PDFNon-screw glenoid augmentation constructs for shoulder instability with bone loss: A biomechanical assessment of static and elastic cerclage constructs.
J Orthop
August 2025
University of Alabama at Birmingham, Department of Orthopaedic Surgery, Birmingham, AL, USA.
Purpose: This study aims to compare the biomechanical performance of elastic and static suture-based cerclage systems to traditional screw constructs in the setting of modeled glenoid bony augmentation.
Methods: Biomechanical testing was conducted on polyurethane cellular foam blocks modeling a 20 % glenoid defect repaired with a coracoid graft. Constructs consisted of an elastic suture-based cerclage, static suture-based cerclage, and a two-screw construct.
High mobility group box 1 (HMGB1) mediates nicotine-induced podocyte injury.
Front Pharmacol
January 2025
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, United States.
Introduction: Cigarette smoking is a well-established risk factor for renal dysfunction. Smoking associated with renal damage bears distinct physiological correlations in conditions such as diabetic nephropathy and obesity-induced glomerulopathy. However, the cellular and molecular basis of such an association remains poorly understood.
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