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Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control.
Gut
January 2025
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
Background: The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogramming strategies focusing on inhibitors of phosphoinositide 3-kinase-gamma (PI3Kγ) due to restricted immune cell expression. Inhibition of PI3Kγ alone is ineffective in PDAC, despite increased infiltration of CD8+ T cells.
View Article and Find Full Text PDFThe General Acceptability and Use of Smartphone App-Delivered Interventions for Gambling in Australia.
J Gambl Stud
January 2025
School of Psychology, Deakin University, 221 Burwood Hwy, Burwood, VIC, 3125, Australia.
Smartphones can extend the reach of evidence-based gambling treatment services, yet the general acceptability of app-delivered gambling interventions remains unknown. This study examined the general acceptability and use of app-delivered gambling interventions, and predictors of both, among 173 Australian adults with a lifetime gambling problem (48.5% male, M = 46.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Insulin resistance (IR) is associated with abnormal tau-phosphorylation and IR markers in AD brain co-localize with neurofibrillary tangles. One strategy to overcome brain IR is to increase brain insulin is via intranasal insulin (INI) administration using specialized intranasal devices that deliver insulin to the brain. Our recent INI vs.
View Article and Find Full Text PDFBackground: The HEAD study aims to collect a large dataset of multiple tau-PET tracers to provide robust anchor values for tau-PET harmonization. Here, we tested the hypothesis that anchoring two tau tracer uptake values using head-to-head measurements has the potential to generate an accurate universal tau-PET scale, named Uniτ(tau).
Methods: We assessed 200 individuals across the aging and AD spectrum (Training: HEAD data freeze 2.
Quantity of Caloric Support After Pediatric Severe Traumatic Brain Injury: Description of Associated Outcomes in a Single Retrospective Center Cohort, 2010-2022.
Pediatr Crit Care Med
January 2025
Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.
Objectives: To examine the relationship between adequacy of caloric nutritional support during the first week after severe traumatic brain injury (TBI) and outcome.
Design: Single-center retrospective cohort, 2010-2022.
Setting: Tertiary care children's hospital with a level 1 trauma center.
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