Eight azukisapogenol triterpene glycosides, including five new compounds, oxychiliotriterpenosides A⁻E (⁻), two new methyl glucuronide derivatives that proved to be artifacts, oxychiliotriterpenoside E-glucuronic acid methyl ester () and myrioside B-glucuronic acid methyl ester (), and a known one, myrioside B (), was isolated from the aerial part of Royle. Their structures were elucidated based on extensive spectroscopic analyses and chemical methods. Triterpene glycosides were first obtained from , and those containing a galactose unit (, , and ) and diglucosidic or triglucosidic linkage at C-29 (⁻), were reported from species for the first time, which might be recognized as a chemotaxonomic feature of . All isolated compounds were evaluated for their anti-inflammatory activities against NO production using lipopolysaccharide (LPS)-induced RAW 264.7 cells, but no compounds showed potent inhibition on NO production.
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| http://dx.doi.org/10.3390/molecules23102448 | DOI Listing |
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