Unlabelled: The aim of this paper was to study gut microbiota composition in patients with different metabolic statuses.
Methods: 92 participants aged 25⁻76 years (26 of whom were men), with confirmed absence of cardiovascular and other chronic diseases (but with the possible presence of cardiovascular risk factors) were included. Carotid ultrasound examinations, 16 rRNA sequencing of stool samples and diet assessments were performed. Statistical analysis was performed using R programming language, 3.1.0.
Results: Enterotyping yielded two clusters differentiated by alpha-diversity. Intima-media thickness was higher in the cluster with lower diversity (adj. < 0.001). Obesity was associated with higher (adj. = 0.003) and (adj. < 0.0003) in relative abundance. Abdominal obesity was associated with higher abundance of (adj. = 0.004) and (adj. = 0.0008) and lower levels of (adj. = 0.0005). Glucose metabolism disturbances were associated with higher (adj. = 0.0007) and (adj. = 0.003) prevalence. Arterial hypertension was associated with high levels (adj. = 0.002). The genus strongly correlated with low resistant starch consumption (adj. = 0.007). A combination of high-fat diet and elevated levels was very common for diabetes mellitus type 2 patients (adj. = 0.0001).
Conclusion: The results show that there is a relationship between metabolic changes and higher representation of opportunistic pathogens and low diversity of gut microbiota even in apparently healthy participants.
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| http://dx.doi.org/10.3390/microorganisms6040098 | DOI Listing |
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