Unlabelled: : Hanging motionless in a full body harness may result in unwanted events, such as acute hypotension and syncope, which has been termed harness suspension stress (HSS). The etiology of HSS has not been explored, and it is unknown if the type of harness influences the HSS response.
Objectives: Evaluate hemodynamics, subjective discomfort, and biological markers of muscle damage during 30-minutes suspension; and evaluate differences between harness attachment (frontal or dorsal).
Methods: Heart rate, blood pressure, biological markers of muscle damage, and subjective discomfort were measured.
Results: Trial time was shorter in the dorsal versus frontal point of attachment. Hemodynamic shift resulted in the dorsal trial which indicated possible perfusion abnormalities.
Conclusions: Hemodynamic adjustments contributed to early termination observed in the dorsal trial. A frontal point of attachment may be more suitable for extended harness exposure.
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http://dx.doi.org/10.1097/JOM.0000000000001459 | DOI Listing |
Mechanobiol Med
December 2024
Department of Biomedical Engineering, College of Engineering and Applied Sciences, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, 11794-5280, USA.
Biomanufacturing relies on living cells to produce biotechnology-based therapeutics, tissue engineering constructs, vaccines, and a vast range of agricultural and industrial products. With the escalating demand for these bio-based products, any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the discipline. While these goals are primarily achieved using or strategies, harnessing cell mechanosensitivity represents a promising - albeit less studied - pathway to promote bioprocessing endpoints, yet identifying which mechanical parameters influence cell activities has remained elusive.
View Article and Find Full Text PDFUrolithiasis
December 2024
Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstr. 6, 8010, Graz, Austria.
The primary objective of urolithiasis therapy is complete stone removal and highest stone-clearance rates possible to minimize recurrence. A novel approach that employs a magnetic suspension and a magnetic probe for the passive collection and removal of small residual fragments was developed. This study assessed the feasibility of this system in porcine models.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Therapeutic Chemistry Department, Pharmaceutical Industries and Drug Research Institute, National Research Centre, Dokki 12622, Cairo, Egypt. Electronic address:
The current study aimed to investigate the therapeutic potential of a novel benzimidazole derivative (BMPE) and a prebiotic bacterial levan (LevAE) against triple-negative breast cancer (TNBC) in a 4T1-cell syngeneic mouse model and to elucidate the immunological and molecular mechanisms underlying the phenotypic changes observed in treated tumors. The metastatic TNBC model was successfully established by subcutaneous inoculation of 100 μl of 4T1 cell suspension (~6000 cells) in the mammary glands of adult female BALB/c mice after brief immunosuppression one day before cell implantation. The therapeutic efficacy of BMPE and LevAE was biochemically, immunologically, and immunohistochemically evaluated.
View Article and Find Full Text PDFNano Lett
December 2024
Department of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, Texas 75235, United States.
Circulating tumor cells (CTCs) are associated with tumor burden and treatment response and, as hallmarks of the initiation of tumor dissemination, can predict the likelihood of metastatic progression before widespread tumors can be detected by standard anatomic imaging. However, early diagnosis of recurrence through the detection of CTCs is limited by their low prevalence in blood and the limited sensitivity of existing technologies. To address these challenges, we investigated the use of ultrasound and targeted microbubbles (MBs) for early CTC detection.
View Article and Find Full Text PDFJ Colloid Interface Sci
February 2025
Physical Chemistry and Soft Matter, Wageningen University & Research, Stippeneng 4, Wageningen, 6708 WE, the Netherlands. Electronic address:
Hypothesis: Films that develop compositional heterogeneity during drying offer a promising approach for achieving tailored functionalities. These functionalities can be realized by strategically directing different components during the drying process. One approach to achieve this is through spontaneous size segregation of colloidal particles.
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