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Persistent microbial infections and idiopathic pulmonary fibrosis - an insight into pathogenesis.
Front Cell Infect Microbiol
January 2025
Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Interstitial lung disease (ILD) is characterized by chronic inflammation and scarring of the lungs, of which idiopathic pulmonary fibrosis (IPF) is the most devastating pathologic form. Idiopathic pulmonary fibrosis pathogenesis leads to loss of lung function and eventual death in 50% of patients, making it the leading cause of ILD-associated mortality worldwide. Persistent and subclinical microbial infections are implicated in the acute exacerbation of chronic lung diseases.
View Article and Find Full Text PDFPediatric Case of Facial Nerve Palsy as a Complication of Acute Otitis Media Caused by Non-typeable Haemophilus Influenza.
Cureus
January 2025
Department of Microbiology, Medical University-Sofia, Sofia, BGR.
Facial paralysis is an infrequent and serious potential complication of acute otitis media (AOM). We describe a pediatric case of rapidly progressive facial paralysis as a secondary complication alongside AOM, caused by the non-typeable (NTHi) strain, which was managed with facial nerve decompression, glucocorticoid medication, and antimicrobial chemotherapy. The reasons why NTHi becomes pathogenic in certain patients are not yet fully understood, and the specific interactions and adaptations that lead to complications must be further investigated, as they result in more complex treatment approaches.
View Article and Find Full Text PDFComparative genomic study of non-typeable in children with pneumonia and healthy controls.
iScience
December 2024
Shantou University Medical College, Shantou University, Shantou, Guangdong 515041, China.
Article Synopsis
- Non-typeable Haemophilus influenzae (NTHi) is a common cause of respiratory infections like pneumonia in kids and can be present in healthy individuals without causing symptoms.
- This study investigates genetic differences between NTHi strains from healthy children compared to those with pneumonia, revealing that about 32% of genes vary between the two groups.
- Key findings include changes in pathogenicity-related pathways and significant mutations in PBP3 that affect antibiotic resistance, suggesting new avenues for targeted treatment and diagnostics.
Correction: Whole-genome sequencing of non-typeable Haemophilus influenzae isolated from a tertiary care hospital in Surabaya, Indonesia.
BMC Infect Dis
November 2024
Eijkman Research Centre for Molecular Biology, National Research and Innovation Agency, Cibinong, West Java, Indonesia.
Middle Ear microRNAs Drive Mucin Gene Response.
Laryngoscope
November 2024
Division of Otolaryngology, Sheikh Zayed Center for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, USA.
Objective(s): To investigate the role of microRNA-378 (miR-378) in the regulation of mucin gene expression and inflammatory response in human middle ear epithelial cells (HMEEC) during bacterial infection by non-typeable Haemophilus influenzae (NTHi).
Methods: Human middle ear epithelial cells (HMEEC) were cultured and transfected with miR-378 or control miRNA. Post-transfection, cells were exposed to NTHi lysates.
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