How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4 T cells and adaptive genetic changes were observed during serial passages.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464631 | PMC |
| http://dx.doi.org/10.1111/jmp.12380 | DOI Listing |
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