AI Article Synopsis
- Several studies indicate that CXCL5, a chemokine expressed in colorectal mucosa, is linked to cell growth and is a potential serum marker for colorectal cancer (CRC) prognosis.
- The study aimed to compare CXCL5 levels in serum and tissue among patients with CRC, colonic adenomas, and normal mucosa, using immunohistochemistry and serum measurements from 68 biopsy samples.
- Results showed elevated CXCL5 and CEA levels in CRC tissues and serum; however, CXCL5's sensitivity and specificity were low, indicating it may not be reliable for early CRC diagnosis.
Article Abstract
Background: Several studies indicate that chemokines play important roles in colorectal mucosal immunity. The chemokine CXCL5 which is expressed by epithelial cells within colorectal mucosa is a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. The purpose of this study was to investigate whether serum and tissue CXCL5 levels is altered in colorectal carcinomas (CRC) compared to colonic adenoma and normal mucosa.It also aimed to compare colon adenoma and colorectal cancer for blood CXCL5 and CEA levels, their sensitivity, and specificity. Methods: CXCL5 expression was assessed with immunohistochemistry staining in biopsy samples taken during colonoscopy in 22 colonic adenomas, 23 colorectal carcinomas and 23 normal colonic tissue samples. Also all patients’ serum CXCL5 and CEA levels were measured. This stduy was prospective observational study. Results: The number of cases who were stained positive with immunohistochemistry was found to be higher in the group with CRC. When compared with the other groups, both levels of serum CXCL5 and CEA were significantly high in the group CRC. Sensitivity and specificity of serum CXCL5 were found to be low as a result of the ROC analysis. Conclusion: Although the level of CXCL5 is high in CRC, its level in serum is not significant enough to support the early diagnosis of the disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249465 | PMC |
| http://dx.doi.org/10.22034/APJCP.2018.19.9.2481 | DOI Listing |
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