In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of -(-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in excellent overall yield and purity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142761 | PMC |
| http://dx.doi.org/10.3762/bjoc.14.209 | DOI Listing |
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