Commensal gut microbiota exerts multifarious effects on intestinal and extra-intestinal immune homeostasis. A disruption in the microbial composition of the gut has been associated with many neurological disorders with inflammatory components. Here we review known associations between gut microbiota and neurological disorders. Further we highlight the emerging role of diet and microbiota interrelationship in regulating neuroinflammation.
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http://dx.doi.org/10.3389/fimmu.2018.02067 | DOI Listing |
Nanoscale
January 2025
Transport at Nanoscale Interfaces Laboratory, Empa, Swiss Federal Laboratories for Materials Science and Technology, 8600 Dübendorf, Switzerland.
Magic-angle twisted bilayer graphene (TBLG) has emerged as a versatile platform to explore correlated electron phases driven primarily by low-energy flat bands in moiré superlattices. While techniques for controlling the twist angle between graphene layers have spurred rapid experimental progress, understanding the effects of doping inhomogeneity on electronic transport in correlated electron systems remains challenging. In this work, we investigate the interplay of confinement and doping inhomogeneity on the electrical transport properties of TBLG by leveraging device dimensions and twist angles.
View Article and Find Full Text PDFBiomol Biomed
December 2024
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Severe acute pancreatitis (SAP) is one of the leading causes of hospital admissions for gastrointestinal diseases, with a rising incidence worldwide. Intestinal microbiota dysbiosis caused by SAP exacerbates systemic inflammatory response syndrome and organ dysfunction. Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic option for gastrointestinal diseases.
View Article and Find Full Text PDFCommun Integr Biol
January 2025
Department of Psychiatry, DeBusk College of Osteopathic Medicine, Harrogate, TN, USA.
Emerging research has highlighted the significant role of microbiota-gut-brain communication in child psychiatric disorders, including autism spectrum disorder (ASD) and anxiety disorders. Despite this, mainstream psychiatric interventions for children continue to focus predominantly on neurological and psychological therapies, neglecting the critical influence of gut microbiota on brain development and behavior. This commentary underscores the need for greater integration of microbiota-targeted therapies, such as dietary interventions, prebiotics, and probiotics, into early psychiatric intervention strategies.
View Article and Find Full Text PDFFront Artif Intell
December 2024
Department of Orthopedic Hip and Knee Surgery, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Background: Total Hip Arthroplasty (THA) is a transformative surgical intervention for hip joint disorders, necessitating meticulous preoperative planning for optimal outcomes. With the emergence of Artificial Intelligence (AI), preoperative planning paradigms have evolved, leveraging AI algorithms for enhanced decision support and imaging analysis. This systematic review aims to comprehensively evaluate the role of AI in THA preoperative planning, synthesizing evidence from studies exploring various AI techniques and their applications.
View Article and Find Full Text PDFExplor Target Antitumor Ther
November 2024
Division of Pulmonary, Critical Care, and Sleep Disorders Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
There has been a rapid expansion of immunotherapy options for non-small cell lung cancer (NSCLC) over the past two decades, particularly with the advent of immune checkpoint inhibitors. Despite the emerging role of immunotherapy in adjuvant and neoadjuvant settings though, relatively few patients will respond to immunotherapy which can be problematic due to expense and toxicity; thus, the development of biomarkers capable of predicting immunotherapeutic response is imperative. Due to the promise of a noninvasive, personalized approach capable of providing comprehensive, real-time monitoring of tumor heterogeneity and evolution, there has been wide interest in the concept of using circulating tumor DNA (ctDNA) to predict treatment response.
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