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, and Gene Polymorphisms and Risk of Retinal Vein Occlusion: A Case-Control Study.
Genes (Basel)
May 2024
2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Numerous studies have tried to evaluate the potential role of thrombophilia-related genes in retinal vein occlusion (RVO); however, there is limited research on genes related to different pathophysiological mechanisms involved in RVO. In view of the strong contribution of oxidative stress and inflammation to the pathogenesis of RVO, the purpose of the present study was to investigate the association of inflammation- and oxidative-stress-related polymorphisms from three different genes [] and the risk of RVO in a Greek population. Participants in this case-control study were 50 RVO patients (RVO group) and 50 healthy volunteers (control group).
View Article and Find Full Text PDFEvaluation of stromal cell-derived factor-1β Gene polymorphism G801A among Egyptian patients with type 2 diabetes mellitus.
Egypt J Immunol
July 2021
Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Stromal cell derived factor - 1 (SDF-1) is expressed by bone marrow derived stromal cells and stromal tissues in multiple organs. SDF-1 possesses diverse physiological and biochemical functions concerning autoimmunity and inflammation. SDF-1 gene polymorphisms play various roles in immune related diseases.
View Article and Find Full Text PDFPotential Protective Role of SDF-1 and CXCR4 Gene Variants in the Development of Dementia.
Psychiatr Danub
April 2020
Department of Medical Biology, Faculty of Medicine, Yeditepe University, İnönü Cad. 26 Ağustos Yerleşkesi, 34755 Kayışdağı-Ataşehir, Istanbul, Turkey.
Background: The aim of this study was to evaluate the role of polymorphisms of stromal cell-derived factor-1 (SDF-1) and chemokine receptor-4 (CXCR4) genes in dementia susceptibility in a Turkish population.
Subjects And Methods: The study group included 61 dementia patients, while the control group comprised 82 healthy individuals. Gene polymorphisms of SDF-1 3'A G801A (rs1801157) and CXCR4 C138T (rs2228014) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
CXCL12 G801A polymorphism is associated with significant liver fibrosis in HIV-infected Thais: a cross-sectional study.
Asian Pac J Allergy Immunol
September 2019
Department of Medical Technology.
Background: Previous studies indicate high prevalence of liver diseases in HIV-infected patients, and their genetic risk factors are still unclear. The chemokine CXCL12 plays important roles in development of chronic liver injury and a single nucleotide polymorphism (SNP) G to A change at position 801 in CXCL12 gene has been demonstrated to affect CXCL12 production levels.
Objective: This study aimed to analyze the association of CXCL12 G801A SNP with liver complication in HIV-infected Thais.
Association of (G801A) and (C825T) polymorphisms with the incidence and severity of coronary artery disease.
Br J Biomed Sci
January 2019
a Department of Biochemistry , Era's Lucknow Medical College and Hospital, Lucknow , India.
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