Introduction: Burns are a very frequent injury type in the battlefield, comprising 5-20% of combat casualties in the recent conflicts. Almost 80% of the burns occur to the face, in part because the face is often not protected. Immediate treatment is critical in the first hours after severe burn injury in order to prevent infection and wound progression. Immediate treatment in the battlefield can be a serious challenge especially if the injury occurs in a remote area with limited transport options. Therefore, novel treatment modalities for prolonged field care when transport to the definitive care is delayed are needed. The purpose of this study was to utilize the platform wound device (PWD) with negative pressure capabilities for the immediate and definitive treatment of porcine full-thickness head burns.
Materials And Methods: Full-thickness burn wounds were created on foreheads of seven Yorkshire pigs. Burns were created on day 0, immediately enclosed with the PWD and treated topically with minocycline and lidocaine. On day 3, the burns were surgically debrided. Subsequently, new PWDs were placed on the wounds and continuous negative pressure wound therapy was initiated with either -50 mmHg or -80 mmHg. On day 7, the animals were euthanized and wounds were harvested for analyses. Control wounds were treated with silver sulfadiazine cream.
Results: The PWD treatment with negative pressure significantly reduced erythema and edema in the injured tissue and promoted granulation tissue and neocollagen formation by day 7 in comparison to control wounds. In addition, the PWD with both topical minocycline and negative pressure (-80 mmHg or -50 mmHg) reduced bacterial counts in the wounds similar to the current standard of care.
Conclusion: This study demonstrates that the PWD is an effective platform for delivery of antibiotics and negative pressure wound therapy for the treatment of full-thickness burns. Therefore, the PWD may be utilized for both prolonged field care and definitive treatment of burn- and blast-injured warfighters.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/milmed/usy242 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Towards repeated clear-cutting of boreal forests - a tipping point for biodiversity?
Biol Rev Camb Philos Soc
January 2025
Section for Genetics and Evolutionary Biology, Department of Biosciences, University of Oslo, P.O. Box 1066 Blindern, Oslo, 0316, Norway.
Boreal forests are important carbon sinks and host a diverse array of species that provide important ecosystem functions. Boreal forests have a long history of intensive forestry, in which even-aged management with clear-cutting has been the dominant harvesting practice for the past 50-80 years. As a second cycle of clear-cutting is emerging, there is an urgent need to examine the effects of repeated clear-cutting events on biodiversity.
View Article and Find Full Text PDFParallel genetic adaptation amid a background of changing effective population sizes in divergent yellow perch () populations.
Proc Biol Sci
January 2025
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-2054, USA.
Aquatic ecosystems are highly dynamic environments vulnerable to natural and anthropogenic disturbances. High-economic-value fisheries are one of many ecosystem services affected by these disturbances, and it is critical to accurately characterize the genetic diversity and effective population sizes of valuable fish stocks through time. We used genome-wide data to reconstruct the demographic histories of economically important yellow perch () populations.
View Article and Find Full Text PDFDiffuse soil pollution from agriculture: Impacts and remediation.
Sci Total Environ
January 2025
Global Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia; crc for Contamination Assessment and Remediation of the Environment (crcCARE), ATC Building, University Drive, Callaghan, NSW 2308, Australia. Electronic address:
Agricultural activities are essential for sustaining the global population, yet they exert considerable pressure on the environment. A major challenge we face today is agricultural pollution, much of which is diffuse in nature, lacking a clear point of origin for chemical discharge. Modern agricultural practices, which often depend on substantial applications of fertilizers, pesticides, and irrigation water, are key contributors to this form of pollution.
View Article and Find Full Text PDFManual Forearm Palpation in Acute Forearm Compartment Syndrome Is Not Accurate: A Cadaveric Study.
J Bone Joint Surg Am
September 2024
Department of Orthopaedic Surgery, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Background: Manual compartment palpation is used as a component of the clinical diagnosis of acute compartment syndrome (ACS), particularly in obtunded patients. However, its utility and accuracy in the upper limb are unknown. The purposes of this study were to assess the accuracy of manual compartment palpation of ACS in the forearm in a cadaveric model and to assess the role of clinician experience in this setting.
View Article and Find Full Text PDFSodium, the Vascular Endothelium, and Hypertension: A Narrative Review of Literature.
Cardiol Rev
January 2025
From the Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX.
The vascular endothelium and its endothelial glycocalyx contribute to the protection of the endothelial cells from exposure to high levels of sodium and help these structures maintain normal function by regulating vascular permeability due to its buffering effect. The endothelial glycocalyx has negative surface charges that bind sodium and limit sodium entry into cells and the interstitial space. High sodium levels can disrupt this barrier and allow the movement of sodium into cells and extravascular fluid.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!