Colon cancer is a heterogeneous tumor driven by subpopulations of cancer stem cells (CSCs). We recently used patient-derived organoids (PDOs) to demonstrate that CSC survival is regulated by autocrine non-canonical Hedgehog signaling, which acts as a positive regulator of Wnt signaling to block CSC differentiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149873 | PMC |
| http://dx.doi.org/10.1080/23723556.2018.1445940 | DOI Listing |
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