Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149877 | PMC |
| http://dx.doi.org/10.1080/23723556.2018.1435184 | DOI Listing |
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