Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149810 | PMC |
| http://dx.doi.org/10.1080/23723556.2017.1327005 | DOI Listing |
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