Patients with high hyperopia are generally confined to either spectacle wear or contact lenses as a primary means of refractive correction. For this patient population, the surgical corrective methods, such as hyperopic laser assisted in-situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) are imperfect options due to induction of higher-order aberrations, optical regression, and loss of best corrected distance visual acuity. Recently, there has been growing interest in lenticule implantation underneath a flap via lenticule intrastromal keratoplasty (LIKE) for high hyperopia correction (+3 diopters to +10 diopters). We instead propose a modified surgical technique (small-incision lenticule intrastromal keratoplasty, sLIKE), in which the lenticule is implanted inside an intrastromal pocket thereby causing less injury to the subbasal nerve plexus injury, less postoperative dry eye symptoms, less reduction in biomechanical strength, and lower chances for epithelial ingrowth. We provide an overview of these novel surgical techniques to treat high hyperopia, and compare the associated advantages and disadvantages. In addition, we will discuss the enhancement options and methods of optimization for both surgical techniques.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146242 | PMC |
Purpose: To evaluate the clinical outcome of laser-assisted surgical correction of high hyperopic or mixed astigmatism using small incision intrastromal lenticule rotation (SMILERO) alone or combined with photorefractive keratectomy (PRK).
Methods: This retrospective case series enrolled 25 eyes with high astigmatism that underwent SMILERO surgery. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected near visual acuity (UNVA), manifest refraction, central corneal thickness, and corneal higher order aberrations were analyzed before surgery and after 3, 6, and 12 months of follow-up.
Ophthalmology
November 2024
Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China; WHO Collaborating Centre for Guideline Implementation and Knowledge Translation, Lanzhou University, Lanzhou, China; Lanzhou University GRADE Center, Lanzhou, China.
Topic: Development of evidence-based guidelines for keratorefractive lenticule extraction (KLEx).
Clinical Relevance: KLEx refers to various corneal refractive procedures involving removal of refractive lenticules of intrastromal corneal tissue, typically through a small incision, thereby eliminating creation of a corneal flap. This technique has rapidly gained popularity as a possible alternative to flap-based procedures; however, no clinical practice guidelines exist for KLEx.
Sci Rep
November 2024
Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Eye Institute, Gansu Road 4, Heping District, Tianjin, 300020, China.
This study aimed to describe a novel sandwich technique of minimally invasive surgical implantation by using corneal stromal lenticules for corneal perforation. This prospective observational study included nine patients aged 23-79 years (mean, 54 ± 9) from Tianjin Eye Hospital. Corneal stromal lenticules with a central thickness of 120 μm were obtained from small incision lenticule extraction(SMILE).
View Article and Find Full Text PDFZhonghua Yan Ke Za Zhi
November 2024
Department of Ophthalmology & Visual Science, Shanghai Medical College of Fudan University, Department of Ophthalmology, Eye & ENT Hospital of Fudan University, NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai 200031, China.
Lenticule intrastromal keratoplasty (LIKE) was introduced clinically in the 1980s as a refractive surgery. With the advancements of femtosecond laser, LIKE has been significantly revitalized. Currently, femtosecond laser-assisted LIKE has been demonstrated to be a safe and effective surgical procedure to correct hyperopia, but the predictability is still a major limitation.
View Article and Find Full Text PDFInt J Mol Sci
June 2024
Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia.
Cell-based therapies using corneal stromal stem cells (CSSC), corneal keratocytes, or a combination of both suppress corneal scarring. The number of quiescent keratocytes in the cornea is small; it is difficult to expand them in vitro in quantities suitable for transplantation. This study examined the therapeutic effect of corneal fibroblasts reversed into keratocytes (rCF) in a mouse model of mechanical corneal injury.
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