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Unsuspecting Plaque on the Forearm: A Diagnostic Challenge.
Indian Dermatol Online J
December 2024
Department of Dermatology, Father Muller Medical College, Mangalore, Karnataka, India.
Microcystic adnexal carcinoma (MAC) is a rare, slow-growing, locally aggressive malignant, and recurring appendageal tumor. Prolonged UV exposure, immunosuppression, and radiotherapy are a few frequently associated risk factors. MAC classically presents as an asymptomatic skin coloured plaque on the face.
View Article and Find Full Text PDFPeriorbital Microcystic Adnexal Carcinoma With Distant Metastases.
Ophthalmic Plast Reconstr Surg
December 2024
Department of Ophthalmology, Liverpool Hospital, Liverpool, New South Wales.
Purpose: Microcystic adnexal carcinoma (MAC) is a locally aggressive adnexal carcinoma of the head and neck, which has a high tendency for recurrence. MAC rarely has distant metastasis, with only one previously reported case originating from the periorbital region. We present a patient with periorbital MAC with distant metastasis and a review of all reported patients with metastatic disease.
View Article and Find Full Text PDFPrimary cutaneous adnexal adenocarcinoma not otherwise specified versus metastatic breast carcinoma: A case report and review of the literature.
JAAD Case Rep
September 2024
Department of Pathology, Stamford Hospital, Stamford, Connecticut.
Squamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal Carcinoma, and Porocarcinoma.
Mod Pathol
November 2024
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
Article Synopsis
- Squamoid eccrine ductal carcinoma is a rare tumor with characteristics that fall between squamous cell carcinoma (SCC) and certain sweat gland carcinomas, leading to debates on its classification.
- The study examined 15 cases of this carcinoma, revealing that most cases had UV signature mutations and TP53 mutations as the most common genetic alterations.
- Transcriptome analysis indicated that this carcinoma expresses 364 genes more and 525 genes less compared to SCC and sweat gland tumors, reinforcing the idea that it has an intermediate phenotype between these cancer types.
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