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Background: Leaf economic theory holds that physiological constraints to photosynthesis have a role in the coordinated evolution of multiple leaf traits, an idea that can be extended to carnivorous plants occupying a particular trait space that is constrained by key costs and benefits. Pitcher traps are modified leaves that may face steep photosynthetic costs: a high-volume, three-dimensional tubular structure may be less efficient than a flat lamina. While past research has investigated the photosynthetic costs of pitchers, the exact suite of constraints shaping pitcher trait variation remain under-explored-including constraints to carnivorous function.
View Article and Find Full Text PDFDistinct neural networks of emotional valence and uncertainty in the human amygdala underlying different mental disorders.
Sci Bull (Beijing)
February 2025
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China; Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK; Zhangjiang Fudan International Innovation Center, Shanghai 200433, China; Fudan ISTBI-ZJNU Algorithm Centre for Brain-inspired Intelligence, Zhejiang Normal University, Hangzhou 321004, China. Electronic address:
Plasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
JAMA Oncol
February 2025
Department of Oncology, UCL Cancer Institute, University College London, London, United Kingdom.
Patient preferences for triple-class-exposed relapsed or refractory multiple myeloma treatment: a discrete-choice study.
Future Oncol
March 2025
Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Aims: To quantify patient preferences for attributes of novel treatments for triple-class-exposed (TCE) relapsed and/or refractory multiple myeloma (RRMM).
Methods: Using a discrete-choice experiment, we elicited preferences for 7 attributes: objective response rate (ORR), overall survival (OS), all-grade cytokine release syndrome risk, all-grade immune effector cell-associated neurotoxicity syndrome risk, serious infection risk (grade 3+), treatment administration, and initial hospitalization requirements.
Results: OS was the most important attribute (conditional relative importance [CRI] 32.
When the wild things are: Defining mammalian diel activity and plasticity.
Sci Adv
February 2025
Department of Fish, Wildlife, and Conservation Biology, Colorado State University, Fort Collins, CO, USA.
Circadian rhythms are a mechanism by which species adapt to environmental variability and fundamental to understanding species behavior. However, we lack data and a standardized framework to accurately assess and compare temporal activity for species during rapid ecological change. Through a global network representing 38 countries, we leveraged 8.
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