Interesting self-assembly of an amino acid based molecular material into a hydrogel in the presence of selective enantiomeric chiral amines leading to chiral recognition has been demonstrated. Moreover, collapse of a metallogel formed from the same material in the presence of selective enantiomers validated its enantioselective affinity. Importantly, in addition to relevant experimental techniques, DFT studies have been successfully explored to establish chiral recognition through enantioselective gelation.
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http://dx.doi.org/10.1039/c8cc06471g | DOI Listing |
Angew Chem Int Ed Engl
January 2025
Nanjing University, School of Chemistry and Chemical Engineering, 163 Xianlin Avenu, 210023, Nanjing, CHINA.
Glycans, unlike uniformly charged DNA and compositionally diverse peptides, are typically uncharged and exhibit rich stereoisomeric diversity in the glycosidic bonds between two monosaccharide units. This heterogeneity of charge and the structural complexity present significant challenges for accurate analysis. Herein, we developed a novel single-molecule oligosaccharide sensor, OmpF nanopore.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
School of Pharmacy, School of Clinical Medicine, Shandong Second Medical University, Weifang, 261053, China. Electronic address:
Chiral isomers show different behaviours and properties in physiological activities. It is of great significance to find productive approach to realize the recognition of enantiomers, which is a key issue in biochemical and pharmaceutical fields. Nowadays, chiral identification can be successfully achieved according to the discrepancies of special signals correlated with different enantiomers of multiple electrode structures.
View Article and Find Full Text PDFAnal Chem
January 2025
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Designing single-template molecularly imprinted chiral sensors for the enantioselective recognition of various chiral amino acids (AAs) is of great importance for chiral analysis. Here, a dummy template-based chiral sensor is developed by using l-alanine (l-Ala) as the dummy template and poly(-phenylenediamine) as the imprinting layer, which can be used for the enantioselective recognition of various chiral AAs such as Ala, tryptophan (Trp), tyrosine (Tyr), cysteine (Cys), and arginine (Arg). Compared with conventional single-template molecularly imprinted chiral sensors, the designed single-template chiral sensor shows great universality for the recognition of chiral AAs since all chiral AAs possess an Ala-analogous segment.
View Article and Find Full Text PDFAnal Chem
January 2025
College of Petrochemical Technology, Lanzhou University of Technology, 730050 Lanzhou, PR China.
Introducing chiral molecules into metal-organic frameworks (MOFs) to obtain chiral MOFs (CMOFs), the tunability of their structures makes them a highly anticipated class of chiral materials for electrochemical sensing. However, the structure of CMOFs is often limited by synthesis challenges, and introducing chiral molecules into MOFs often leads to a decrease in their internal space. This study introduces a defect engineering strategy into the synthesis of CMOFs to obtain CMOFs with defects, which is an efficient synthesis method.
View Article and Find Full Text PDFDalton Trans
January 2025
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Assembling chiral coordination polymers into nano/microflower structures may improve their performance in applications such as chiral recognition and separation. In this study, we chose a chiral metal phosphonate system, , In(NO)/-, -pempH [pempH = (1-phenylethylamino)methylphosphonic acid], and carried out systematic work on the self-assembly of this system in different alcohol/HO mixed solvents under solvothermal conditions. Enantiomeric compounds -, -[In(pempH)(μ-OH)(HO)](NO) (R-, S-1) were obtained showing dense layered structures, but their morphologies varied with alcohol solvent.
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