AI Article Synopsis
- SGK family proteins, particularly SGK3, have similar structures and functions to AKT and are involved in the PI3K signaling pathway, which is crucial for cell growth and survival.
- These proteins play an important role in cancer development by regulating essential cellular processes like proliferation and survival.
- The study focuses on the role of SGK3 in cancer progression and compares its functions with AKT in regards to cell cycle regulation and potential cancer treatments.
Article Abstract
The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146383 | PMC |
| http://dx.doi.org/10.1016/j.apsb.2018.07.001 | DOI Listing |
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