Background: The objective of this study is to observe if mild hyperuricemia and a high-fructose diet influence the cardiovascular and metabolic systems in hypogonadic female Wistar rats compared to normogonadic female rats.
Methods: Fifty-six (56) adult female Wistar rats were used in the present work. Animals were divided into two groups: normogonadic (NGN) and hypogonadic (HGN). These groups were also divided into four subgroups in accordance with the treatment: control with only water (C), fructose (F), oxonic acid (OA), and fructose + oxonic acid (FOA). Lipid profile, glycemia, uric acid, and creatinine determinations were assessed. Cardiovascular changes were evaluated by measuring blood pressure, myocyte volume, fibrosis, and intima-media aortic thickness.
Results: HGN rats had higher levels of total cholesterol (TC) ( < 0.01) and noHDLc ( < 0.01), in addition to higher levels of uric acid ( < 0.05). The OA group significantly increased myocyte volume ( < 0.0001) and the percentage of fibrosis as well as the group receiving FOA ( < 0.001) in both gonadal conditions, being greater in the HGN group. Hypogonadic animals presented a worse lipid profile.
Conclusion: Mild hyperuricemia produces hypertension together with changes in the cardiac hypertrophy, fibrosis, and increased thickness of the intima media in hypogonadic rats fed high-fructose diet.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136543 | PMC |
| http://dx.doi.org/10.1155/2018/6021259 | DOI Listing |
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