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| http://dx.doi.org/10.1016/j.ymthe.2018.09.007 | DOI Listing |
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: Developing ex vivo models that replicate immune-tumor interactions with high fidelity is essential for advancing immunotherapy research, as traditional two-dimensional in vitro systems often lack the complexity required to fully represent these interactions. : In this study, we establish a comprehensive 3D redirect lysis (3D-RDL) assay using colorectal cancer spheroids and adult stem cell-derived, healthy human organoids to evaluate the efficacy and safety profile of , a bispecific antibody targeting carcinoembryonic antigens (CEAs) on cancer cells and CD3 on T cells. This model allows us to assess cytotoxic activity and immune responses, capturing variations in therapeutic response not observable in simpler systems.
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Department of Environmental and Safety Engineering, Ajou University, Suwon 16499, Republic of Korea.
The demand for the use of secondary batteries is increasing rapidly worldwide in order to solve global warming and achieve carbon neutrality. Major minerals used to produce cathode materials, which are key raw materials for secondary batteries, are treated as conflict minerals due to their limited reserves, and accordingly, research on the battery recycling industry is urgent for the sustainable secondary battery industry. There is a significant risk of accidents because there is a lack of prior research data on the battery recycling process and various chemicals are used in the entire recycling process.
View Article and Find Full Text PDFDrillers and bulldozer operators have experienced exceptionally high exposures to respirable crystalline silica in US surface coal mines.
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School of Public Health, Division of Environmental and Occupational Health Sciences, University of Illinois Chicago, Chicago, Illinois, USA.
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Bronchopulmonary dysplasia (BPD) is a condition of poor alveolar formation that causes chronic breathing impairment in infants born prematurely. Preterm lungs lack surfactant and are vulnerable to oxidative injuries driving the development of BPD. Our recent studies reported that surfactant protein A (SP-A) genetic variants influence susceptibility to neonatal lung disease.
View Article and Find Full Text PDFUnderstanding the social networks that contribute to diversion in hospital inpatient pharmacies: A social network analysis.
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HumanEra, Research and Innovation, North York General Hospital, Toronto, Ontario, Canada.
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