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From smog to scarred hearts: unmasking the detrimental impact of air pollution on myocardial ischemia-reperfusion injury.
Cell Mol Life Sci
January 2025
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Air pollution is a global environmental health hazard associated with elevated cardiovascular morbidity and mortality. Emerging evidence suggests that exposure to various air pollutants, specifically particulate matter (PM), ultrafine particulate matter (UFPM), and diesel exhaust particles, may exacerbate myocardial ischemia-reperfusion (I/R) injury. PM exposure can directly impair cardiomyocyte survival under ischemic conditions by inducing inflammation, oxidative stress, apoptosis, and dysregulation of non-coding RNAs.
View Article and Find Full Text PDFAcute and chronic cannabis vapor exposure produces immediate and delayed impacts on phases of fear learning in a sex specific manner.
Psychopharmacology (Berl)
January 2025
Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada.
Rationale: Current treatment options for PTSD have unreliable efficacy, with many individuals unable to achieve complete remission. Cannabis and cannabinoids that act through the endogenous cannabinoid (endocannabinoid) system to help promote trauma recovery by means of enhanced extinction learning are potential therapeutic, pharmacological candidates. Using a preclinical model of translationally-relevant cannabis administration in rodents, we examined the impact of cannabis exposure on aversive memory.
View Article and Find Full Text PDFGestational arsenite exposure alters maternal postpartum heart size and induces Ca-handling dysregulation in cardiomyocytes.
Am J Physiol Heart Circ Physiol
January 2025
Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
Cardiovascular disease is the leading cause of mortality in the US. Studies suggest a role for environmental exposures in the etiology of cardiovascular disease, including exposure to arsenic through drinking water. Arsenic exposure during pregnancy has been shown to have effects on offspring, but few studies have examined impacts on maternal cardiovascular health.
View Article and Find Full Text PDFScreening for Endocrine Bioactivity Potential of Tobacco Product Chemicals Including Flavor Chemicals.
Environ Toxicol
January 2025
Center for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland, USA.
Adolescence and pregnancy involve elevated levels of hormones (e.g., estrogen, androgen) during which exposure to endocrine disruptors could have long-term developmental and reproductive toxicity (DART) effects.
View Article and Find Full Text PDFThe effect of wildfire smoke on children's health: A systematic review.
Paediatr Perinat Epidemiol
January 2025
California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, Sacramento, California, USA.
Background: With wildfires increasing globally due to climate change, children may be more behaviourally exposed and more physiologically vulnerable to adverse health outcomes.
Objective: To complete a comprehensive investigation of epidemiological studies examining respiratory and non-respiratory impacts of wildfires to identify research gaps and inform decision-making to protect children's health.
Data Sources: The databases searched were PubMed, Embase, Scopus and Google Scholar.
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