AI Article Synopsis
- Diterpenoids are bioactive natural compounds known for their diverse biological effects, including antitumor and anti-inflammatory activities.
- Significant research has focused on modifying these compounds to create derivatives with enhanced therapeutic potential, particularly the enmein-type 6,7-seco-ent-kaurane diterpenoids.
- The review summarizes both the natural and synthetic enmein-type diterpenoids, highlighting their promising biological activities and the need for continued research in this area.
Article Abstract
Diterpenoids are important and widely distributed natural compounds with various biological effects, including antitumor, anti-inflammatory and so on. Great efforts have been put in phytochemistry research on diterpenoids. A number of structural modified derivatives and pharmacophore incorporated hybrids were also designed and synthesized with promising therapeutic effects. Among the hopefuls, enmein-type 6,7-seco-ent-kaurane diterpenoids with unique ring system and stereogenic centers exhibit attractive activities. Based on their lead-like properties, enmein-type diterpenoids are suitable for further medicinal study. The derivatives were biologically evaluated and showed promising activities, which warranted in-depth research for further understanding. In this review, the natural bioactive enmein-type diterpenoids and the synthetic derivatives were comprehensively summarized.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12272-018-1078-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioactive enmein-type 6,7-seco-ent-kaurane diterpenoids: natural products, synthetic derivatives and apoptosis related mechanism.
Arch Pharm Res
November 2018
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
Article Synopsis
- Diterpenoids are bioactive natural compounds known for their diverse biological effects, including antitumor and anti-inflammatory activities.
- Significant research has focused on modifying these compounds to create derivatives with enhanced therapeutic potential, particularly the enmein-type 6,7-seco-ent-kaurane diterpenoids.
- The review summarizes both the natural and synthetic enmein-type diterpenoids, highlighting their promising biological activities and the need for continued research in this area.
Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys.
J Nat Prod
January 2016
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
Thirty-two enmein-type ent-kaurane diterpenoids, including 13 new compounds, were isolated from the aerial parts of Isodon phyllostachys. Compounds 1 and 2 are the first examples of 3,20:6,20-diepoxyenmein-type ent-kauranoids, and the structures of these new compounds were established mainly by analyzing NMR and HREIMS data. The absolute configurations of 1 and 8 and the relative configuration of 9 were determined using single-crystal X-ray diffraction.
View Article and Find Full Text PDFBioactive ent-kaurane diterpenoids from Isodon rosthornii.
J Nat Prod
July 2013
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis. The relative configuration of 2 and the absolute configuration of 3 were determined by single-crystal X-ray diffraction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!