Carbohydr Polym
College of Life Science, Shandong Agricultural University, Taian, 271018, PR China. Electronic address:
Published: December 2018
The present work investigated the antioxidant and hepatoprotective effects of acidic- and enzymatic-hydrolysis mycelium polysaccharide (AcMPS and EnMPS) from Pleurotus geesteranus on alcoholic liver disease (ALD) mice. The animal studies demonstrated that the polysaccharides had potential effects reflected by remitting alcoholic hepatitis, reducing lipid accumulation, preventing oxidative stress, improving inflammatory symptoms, and alleviating the liver functions by histopathologic observation. Results showed that AcMPS (yield of 84%) was composed of L-Rha, D-Rib, L-Ara, D-Glc, D-Man and D-Gal with the Mw of 3.49 × 10 Da, while EnMPS (yield of 90%) was contained L-Rha, L-Ara, D-Gal and D-Glc with the Mw of 3.67 × 10 Da. Furthermore, the GC-MS analysis indicated that both AcMPS and EnMPS were β-pyranoside polysaccharides with the (1→3)- and (1→6)-linkages. The conclusions indicated that AcMPS and EnMPS could be used as natural drugs for preventing the ALD, and providing underlying hepatoprotective mechanisms, pharmaceutically.
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http://dx.doi.org/10.1016/j.carbpol.2018.08.058 | DOI Listing |
Carbohydr Polym
January 2019
College of Life Science, Shandong Agricultural University, Taian, 271018, PR China. Electronic address:
The present work investigated the antioxidative, anti-inflammatory and pulmonary protective effects of enzymatic- and acid- hydrolysed mycelia polysaccharides (En-MPS and Ac-MPS) from Oudemansiella radicata on LPS-induced acute lung injury (ALI) mice. The results demonstrated that both En-MPS and Ac-MPS showed potential pulmonary protective effects by decreasing serum levels of hs-CRP and C3, increasing pulmonary enzyme values of SOD, GSH-Px, CAT and the level of T-AOC; reducing the activity of MPO; and down-regulating the contents of MDA and LPO. In addition, the levels of TNF-ɑ, IL-1β, and IL-6 in BALF of mice treated with En-MPS at a dosage of 400 mg/kg/d were significantly lower than those in the ALI mice.
View Article and Find Full Text PDFCarbohydr Polym
December 2018
College of Life Science, Shandong Agricultural University, Taian, 271018, PR China. Electronic address:
The present work investigated the antioxidant and hepatoprotective effects of acidic- and enzymatic-hydrolysis mycelium polysaccharide (AcMPS and EnMPS) from Pleurotus geesteranus on alcoholic liver disease (ALD) mice. The animal studies demonstrated that the polysaccharides had potential effects reflected by remitting alcoholic hepatitis, reducing lipid accumulation, preventing oxidative stress, improving inflammatory symptoms, and alleviating the liver functions by histopathologic observation. Results showed that AcMPS (yield of 84%) was composed of L-Rha, D-Rib, L-Ara, D-Glc, D-Man and D-Gal with the Mw of 3.
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