Extracellular Vesicles for Research on Psychiatric Disorders.

Schizophr Bull

Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD.

Published: January 2019

AI Article Synopsis

  • Extracellular vesicles (EVs) are gaining importance for their roles in intercellular communication and potential as diagnostic tools, especially in cancer and neurological disorders.
  • The article reviews key findings on the biology of EVs, their research methods, and their impact on brain cell functions and dysfunctions.
  • Further studies on EVs could enhance our understanding of communication in healthy and diseased brains and lead to new biomarkers and therapies for psychiatric disorders.

Article Abstract

Extracellular vesicles (EVs) have gained increasing attention as underexplored intercellular communication mechanisms in basic science and as potential diagnostic tools in translational studies, particularly those related to cancers and neurological disorders. This article summarizes accumulated findings in the basic biology of EVs, EV research methodology, and the roles of EVs in brain cell function and dysfunction, as well as emerging EV studies in human brain disorders. Further research on EVs in neurobiology and psychiatry may open the door to a better understanding of intercellular communications in healthy and diseased brains, and the discovery of novel biomarkers and new therapeutic strategies in psychiatric disorders.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293232PMC
http://dx.doi.org/10.1093/schbul/sby127DOI Listing

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